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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of a measles-smallpox vaccination campaign by a sero-epidemiologic method
American Journal of Epidemiology, Volume 102, No. 6, Year 1975
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Description
Breman, J. G. (Bureau of Smallpox Eradication, CDC, Atlanta. GA 30333), E. Coffi, R. Bomba-lre K, S. O. Foster and K. L. Herrmann. Evaluation of a measles-smallpox vaccination campaign by a sero-epidemiologic method.Am J Epidemiol 102:564-571, 1975.An assessment technique has been devised whereby children from 30 randomly chosen sampling sites are visited within three days of measles-smallpox vaccination and one month later. Vaccination coverage is measured at house visits and immunologic status is determined by collection of early and late blood samples on filter papers from substratified children in priority age-groups, and by looking at vaccination scars. The methodology was employed in a rural area of the Ivory Coast during the maintenance phase of a measles-smallpox vaccination program; 1762 children from 0-72 months old were inspected. Children in the target age groups, 6-24 months, had a vaccination coverage of 53.6% whereas children outside of the target group had a 10.5% coverage. Of 571 target age children, 94.6% had a measles hemagglutination-inhibition antibody titer of less than 1:10 dilution at the first visit, and were presumed susceptible to measles or vaccine. Of 247 substratified children 6-8 months, 98.3% were susceptible to measles before vaccination; 84.3% of 127 vaccinated children in this age-group sero-converted when re-tested. Of 324 children 9-24 months, 91.7% were susceptible before the campaign; 94.7% of 170 vaccinated children in this age-group converted. A positive history of prior measles or prior measles-vaccination was not a good indicator of measles serologic status. The smallpox vaccination major reaction rate was 93.2%; 91.4% of children with a recent vaccination scar sero-converted to measles vaccine. Thus, the smallpox scar read at the second visit proved the best clinical marker for determining both coverage and immunologic effectiveness of the campaign. © 1975, by The Johns Hopkins University School of Hygiene & Public Health.
Authors & Co-Authors
Breman, Joel G.
United States, Atlanta
Centers for Disease Control and Prevention
Coffi, Emmou
Cote D'ivoire, Abidjan
Médecin Chef
Koi, RAPHAEL BOMBA IRE
Cote D'ivoire, Abidjan
Institut D'hygiéne Sociale
Foster, Stanley O.
Bangladesh, Dhaka
Who
Herrmann, Kenneth L.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 11
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1093/oxfordjournals.aje.a112194
ISSN:
00029262
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Ivory Coast