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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Attribution of hepatitis C virus seroconversion risk in young injection drug users in 5 US cities
Journal of Infectious Diseases, Volume 201, No. 3, Year 2010
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Description
Background. In studies of hepatitis C virus (HCV) seroconversion in injection drug users (IDUs), some have questioned whether underreporting of syringe sharing, a stigmatized behavior, has led to misattribution of HCV risk to other injection-related behaviors. Methods. IDUs aged 15-30 years who were seronegative for human immunodeficiency virus and HCV antibodies were recruited into a prospective study in 5 US cities. Behavioral data were collected via computer-assisted self-interviewing to reduce socially desirable reporting. Hazard ratios (HRs) were estimated to assess associations between behavior and HCV seroconversion. Because the shared use of cookers, cottons, and rinse water was highly correlated, a summary variable was created to represent drug preparation equipment sharing. Results. Among 483 IDUs who injected during the period covered by the follow-up assessments, the incidence of HCV infection was 17.2 cases per 100 person years; no HIV seroconversions occurred. Adjusting for confounders, the shared use of drug preparation equipment was significantly associated with HCV seroconversion (adjusted HR, 2.66; 95% confidence interval, 1.03-23.92), but syringe sharing was not (adjusted HR, 0.91). We estimated that 37% of HCV seroconversions in IDUs were due to the sharing of drug preparation equipment. Conclusions. Associations between sharing drug preparation equipment and HCV seroconversion are not attributable to underascertainment of syringe sharing. Avoiding HCV infection will require substantial reductions in exposure to all sources of contaminated blood. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Hagan, Holly C.
United States, New York
New York University
United States, New York
Nyu Rory Meyers College of Nursing
Pouget, Enrique Rodriguez
United States, New York
National Development and Research Institutes, Inc.
Williams, Ian T.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
Garfein, Richard S.
United States, Atlanta
National Center for Hiv, Viral Hepatitis, Std, and tb Prevention
United States, Los Angeles
University of California, Los Angeles
Strathdee, Steffanie Anne
United States, Los Angeles
University of California, Los Angeles
Hudson, Sharon M.
United States, Chicago
University of Illinois at Chicago
Latka, Mary H.
United States, New York
Nyu Rory Meyers College of Nursing
Ouellet, Lawrence J.
South Africa, Johannesburg
The Aurum Institute
Statistics
Citations: 115
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1086/649783
ISSN:
00221899
Research Areas
Environmental
Infectious Diseases
Study Design
Cohort Study