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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
CDX-2 expression is a common event in primary intestinal-type endocervical adenocarcinoma
American Journal of Clinical Pathology, Volume 132, No. 4, Year 2009
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Description
We studied the expression of cytokeratin (CK) 7, CK20, CDX-2, and p16 in 119 cervical adenocarcinomas (65 usual type [50 invasive; 15 in situ], 37 intestinal type [21 invasive; 16 in situ], 10 endometrioid, 5 adenosquamous, and 2 signet-ring carcinomas) in comparison with 55 cases of rectal adenocarcinomas. The percentage of cells staining was considered negative if 0% to 5% stained; more than 5% was considered positive. For p16, staining of more than 50% was considered positive. CK7 was expressed in all cervical cases and in 12 rectal adenocarcinomas (22%). CK20 was expressed in 17 cervical adenocarcinomas (14.3%) and in 48 rectal adenocarcinomas (87%). CK20 immunostaining was diffuse in the majority of rectal tumors but focal in most cervical tumors. CDX-2 was expressed in all cases of rectal adenocarcinoma and in 46 cervical adenocarcinomas (38.7%): usual type, 10 (15%); intestinal type, 31 (84%); endometrioid type, 5 (50%); adenosquamous and signet-ring types, 0 (0%). CDX-2 is a marker for intestinal differentiation irrespective of a rectal or cervical origin. Therefore, it should not be used as the sole basis to confirm the colorectum as the primary origin in metastatic cases. © American Society for Clinical Pathology.
Authors & Co-Authors
Saad, Reda S.
Egypt, Alexandria
Alexandria University
Canada, Toronto
Sunnybrook Health Sciences Centre
Ismiil, Nadia D.
Canada, Toronto
Sunnybrook Health Sciences Centre
Dubé, Valérie
Canada, Toronto
Sunnybrook Health Sciences Centre
Nofech-Mozes, Sharon
Canada, Toronto
Sunnybrook Health Sciences Centre
Khalifa, Mahmoud A.
Canada, Toronto
Sunnybrook Health Sciences Centre
Statistics
Citations: 18
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1309/AJCP7E5ASGOENPFP
ISSN:
00029173