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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pediatric rhabdomyosarcoma in Morocco
Pediatric Blood and Cancer, Volume 54, No. 1, Year 2010
Notification
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Description
Background. Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the first two decades of life. There is, however, a paucity of reports on the pattern of its occurrence in Africa. This study analyses the epidemiological pattern, clinical features, histology, and outcome in Moroccan children presenting with RMS. Methods. We retrospectively studied 100 consecutive cases of histologically proven RMS in previously untreated children <15 years old followed at the Pediatric Oncology Unit of the Children's Hospital of Rabat from January 1995 to December 2004. Results. RMS represented 5% of all the patients treated for cancer during this period. The male/female ratio was 2:1 with a mean age at diagnosis of 5 years. The embryonal subtype was the most frequent (73%) and the head and neck was the most common site of disease, followed by the genito-urinary tract and limbs. Chemotherapy was used in all patients; 44% also had a radical surgery and 23% radiation therapy. The event-free survival (EFS) at 10 years was 39% with relapse as the first cause of treatment failure. The overall survival at 10 years was 70%. The rate of treatment abandonment was 37%. Conclusion. Epidemiology and clinical features of RMS in Moroccan children does not differ from others countries. However, EFS is lower than that reported elsewhere due to occasional lack of availability of drugs, inadequate local control, and abandonment. © 2009 Wiley-Liss, Inc.
Authors & Co-Authors
Hessissen, Laila
Morocco, Rabat
Children's Hospital of Rabat
Kanouni, Lamia
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
Kili, Amina
Morocco, Rabat
Children's Hospital of Rabat
Nachef, Mohamed Nacer
Morocco, Rabat
Children's Hospital of Rabat
El-Khorassani, Mohammed
Morocco, Rabat
Children's Hospital of Rabat
Benjaafar, Noureddine
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
Khattab, Mohammed El
Morocco, Rabat
Children's Hospital of Rabat
Elgueddari, Brahim El Khalil
Morocco, Agdal Rabat
National Institute of Oncology, Rabat
Statistics
Citations: 23
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1002/pbc.22173
ISSN:
15455009
e-ISSN:
15455017
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Locations
Morocco
Participants Gender
Male
Female