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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality
JACC: Heart Failure, Volume 11, No. 7, Year 2023
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Description
Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure. Objectives: The authors aimed to explore whether ImP is associated with heart failure and mortality. Methods: ImP serum measurements in 2 large and independent clinical cohorts of patients (European [n = 1,985] and North American [n = 2,155]) with a range of severity of cardiovascular disease including heart failure. Univariate and multivariate Cox regression analyses were performed to delineate the impact of ImP on 5-year mortality in the North American cohort, independent of other covariates. Results: ImP is independently associated with reduced ejection fraction and heart failure in both cohorts, even after adjusting for traditional risk factors. Elevated ImP was a significant independent predictor of 5-year mortality (for the highest quartile, adjusted HR: 1.85 [95% CI: 1.20-2.88]; P < 0.01). Conclusions: The gut microbial metabolite ImP is increased in individuals with heart failure and is a predictor of overall survival. © 2023 The Authors
Authors & Co-Authors
Molinaro, Antonio
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Nielsen, Trine G.
Denmark, Copenhagen
Københavns Universitet
Henricsson, Marcus
Sweden, Gothenburg
Göteborgs Universitet
Köber, Lars Valeur
Denmark, Copenhagen
Copenhagen University Hospital
Isnard, Richard N.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Stumvoll, Michael W.
Germany, Leipzig
Universität Leipzig
Pedersen, Oluf Borbye
Denmark, Copenhagen
Københavns Universitet
Smith, Jacqueline Gustav
Sweden, Gothenburg
Göteborgs Universitet
Sweden, Lund
Skånes Universitetssjukhus
Sweden, Lund
Lunds Universitet
Tang, W. H.Wlison
United States, Cleveland
Cleveland Clinic Foundation
Cleḿent, Karine
France, Paris
Inserm
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Hazen, Stanley L.
United States, Cleveland
Cleveland Clinic Foundation
Bastard, Jean Philippe
Unknown Affiliation
Blüher, Matthias
Unknown Affiliation
Coelho, Luis Pedro
Unknown Affiliation
Collet, Jean Philippe
Unknown Affiliation
Dumas, Marc Emmanuel
Unknown Affiliation
Ehrlich, Stanislav Dusko
Unknown Affiliation
Engelbrechtsen, Line
Unknown Affiliation
Fézeu, Léopold K.
Unknown Affiliation
Forslund, Sofia Kirke
Unknown Affiliation
Galán, Pilar Redondo
Unknown Affiliation
Giral, Philippe
Unknown Affiliation
Hansen, Torben
Unknown Affiliation
Holmes, Bridget Anna
Unknown Affiliation
Holst, Jens Juul
Unknown Affiliation
Hoyles, Lesley
Unknown Affiliation
Hulot, Jean Sebastien
Unknown Affiliation
Kerneis, Mathieu
Unknown Affiliation
Kuhn, Michael
Unknown Affiliation
Markó, Lajos
Unknown Affiliation
Moitinho-Silva, Lucas
Unknown Affiliation
Neves, Ana Luísa
Unknown Affiliation
Olanipekun, Michael T.
Unknown Affiliation
Oppert, Jean Michel
Unknown Affiliation
Poitou, Christine
Unknown Affiliation
Silvain, Johanne
Unknown Affiliation
Statistics
Citations: 4
Authors: 36
Affiliations: 11
Identifiers
Doi:
10.1016/j.jchf.2023.03.008
ISSN:
22131779
Research Areas
Noncommunicable Diseases
Study Design
Cohort Study