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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HIV impact on acute morbidity and pelvic tumor control following radiotherapy for cervical cancer
Gynecologic Oncology, Volume 100, No. 2, Year 2006
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Description
Objective. To determine the impact of HIV infection on acute morbidity and pelvic tumor control following external beam radiotherapy (EBRT) for cervical cancer. Method. 218 patients receiving EBRT who also had HIV testing after informed consent was obtained were evaluated. Acute treatment toxicity was documented weekly during treatment and 1 month post-EBRT. Pelvic tumor control was documented at 4 and 7 months post-EBRT. Clinicians were blinded for HIV results. Results. About 20% of the patients were HIV-positive. Overall, 53.4% of the patients had radiation-related acute toxicity (grade 3-4). HIV infection was associated with a 7-fold higher risk of multisystem toxicity: skin, gastrointestinal tract (GIT) and genitourinary tract (GUT) systems. It was also an independent risk factor for treatment interruptions (adjusted relative risk 2.2). About 19% of the patients had residual tumor at 4 and 7 months post-EBRT. HIV infection was independently and significantly associated with 6-fold higher risk of residual tumor post-EBRT. The hazard ratio of having residual tumor after initial EBRT was 3.1-times larger for HIV-positive than for HIV-negative patients (P = 0.014). Conclusion. HIV is associated with increased risk of multisystem radiation-related toxicity; treatment interruptions and pelvic failure (residual tumor) following EBRT. HIV infection is an adverse prognostic factor for outcome of cervical cancer treatment. © 2005 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Gichangi, Peter B.
Kenya, Nairobi
University of Nairobi
Bwayo, Job J.
Kenya, Nairobi
University of Nairobi
Estambale, Benson B.A.
Kenya, Nairobi
University of Nairobi
Rogo, Khama O.
Kenya, Nairobi
Nairobi Oncology Center
Njuguna, Eliud M.
Kenya, Nairobi
Kenyatta National Hospital
Ojwang, Shadrack B.O.
Kenya, Nairobi
University of Nairobi
Temmerman, Marleen I.L.
Belgium, Ghent
Universiteit Gent
Statistics
Citations: 59
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/j.ygyno.2005.10.006
ISSN:
00908258
e-ISSN:
10956859
Research Areas
Cancer
Environmental
Infectious Diseases