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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
AIDS alters the commensal plasma virome
Journal of Virology, Volume 87, No. 19, Year 2013
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Description
We compared the plasma viromes of HIV-infected subjects with low versus high CD4+ T cell counts from the United States and Uganda by using deep sequencing and detected HIV, hepatitis C virus, hepatitis B virus, GB virus C, anellovirus, and human endogenous retrovirus (HERV) reads. An increase in the proportion of reads for anelloviruses, a family of highly prevalent and genetically diverse human viruses, was seen in subjects with AIDS from both countries. The proportion of endogenous human retrovirus reads was increased in AIDS subjects from Uganda but not the United States. Progression to AIDS is therefore associated with changes in the plasma concentration of commensal viruses. © 2013, American Society for Microbiology.
Authors & Co-Authors
Li, Linlin
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
Ucsf School of Medicine
Deng, Xutao
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
Ucsf School of Medicine
Linsuwanon, Piyada
Thailand, Bangkok
Chulalongkorn University
Bangsberg, David R.
United States, Cambridge
Harvard University
Bwana, Mwebesa Bosco
Uganda, Mbarara
Mbarara University of Science and Technology
Hunt, Peter W.
United States, San Francisco
San Francisco General Hospital and Trauma Center
Martin, Jeffrey N.
United States, San Francisco
University of California, San Francisco
Deeks, Steven G.
United States, San Francisco
San Francisco General Hospital and Trauma Center
Delwart, E. L.
United States, San Francisco
Vitalant Research Institute
United States, San Francisco
Ucsf School of Medicine
Statistics
Citations: 93
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.1128/JVI.01839-13
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases
Study Locations
Uganda