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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Treatment of chronic hepatitis C using a 4-week lead-in with nitazoxanide before peginterferon plus nitazoxanide
Journal of Clinical Gastroenterology, Volume 44, No. 7, Year 2010
Notification
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Description
GOALS: The primary aim of this study was to further evaluate the efficacy of peginterferon plus nitazoxanide without ribavirin using a 4-week lead-in. BACKGROUND: The initial treatment of chronic hepatitis C with nitazoxanide used 12 weeks of nitazoxanide monotherapy before combination therapy with peginterferon with or without ribavirin. STUDY: This open-label pilot study enrolled 44 treatment-naive patients with chronic hepatitis C (40 with genotype 4; 3 with genotype 1; and 1 with genotype 2). The patients received oral nitazoxanide 500 mg twice daily for 4 weeks followed by nitazoxanide plus peginterferon alfa-2a 180 μg weekly for 36 weeks and were then followed for 24 weeks. The results of this study were compared with those from an overlapping historical trial using 12 weeks of nitazoxanide lead-in. RESULTS: A sustained virologic response (SVR) was achieved in 80% of patients, which was similar to the SVR rates in the historical trial, that is, 79% and 61% in patients treated with and without ribavirin, respectively. A rapid virologic response occurred in 59% of patients, which was also similar to the rapid virologic response rates in the historical trial (64% and 54% in patients treated with and without ribavirin, respectively). All 4 patients with genotypes 1 and 2 had an SVR. CONCLUSIONS: The nitazoxanide lead-in phase before combination therapy with peginterferon can likely be reduced from 12 weeks to 4 weeks without compromising virologic response rates. In addition, treatment of chronic hepatitis C with peginterferon plus nitazoxanide without ribavirin is promising and requires further study. © 2010 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Rossignol, Jean François A.
United States, Tampa
Romark Institute for Medical Research
United States, Stanford
Stanford University School of Medicine
Elfert, Asem Ahmed
Egypt, Tanta
Faculty of Medicine
Keeffe, Emmet B.
United States, Tampa
Romark Institute for Medical Research
United States, Stanford
Stanford University School of Medicine
Statistics
Citations: 40
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1097/MCG.0b013e3181bf9b15
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases