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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Evaluation of the cytotoxic effect and antibacterial, antifungal, and antiviral activities of Hypericum triquetrifolium Turra essential oils from Tunisia
BMC Complementary and Alternative Medicine, Volume 13, Article 24, Year 2013
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Description
Background: A number of bio-active secondary metabolites have been identified and reported for several Hypericum species. Many studies have reported the potential use of the plant extracts against several pathogens. However, Hypericum triquetrifolium is one of the least studied species for its antimicrobial activity. The aim of the present study was to evaluate the cytotoxic effect of the essential oils of Hypericum triquetrifolium as well as their antimicrobial potential against coxsakievirus B3 and a range of bacterial and fungal strains.Methods: The essential oils of Hypericum triquetrifolium harvested from five different Tunisian localities (Fondouk DJedid, Bou Arada, Bahra, Fernana and Dhrea Ben Jouder) were evaluated for their antimicrobial activities by micro-broth dilution methods against bacterial and fungal strains. In addition, the cytotoxic effect and the antiviral activity of these oils were carried out using Vero cell lines and coxsakievirus B3.Results: The results showed a good antibacterial activities against a wide range of bacterial strains, MIC values ranging between 0.39-12.50 mg/ml and MBC values between 1.56-25.0 mg/ml. In addition, the essential oils showed promising antifungal activity with MIC values ranging between 0.39 μg/mL and 12.50 μg/mL; MFC values ranged between 3.12 μg/mL and 25.00 μg/mL; a significant anticandidal activity was noted (MIC values comprised between 0.39 μg/mL and 12.50 μg/mL). Although their low cytotoxic effect (CC50 ranged between 0.58 mg/mL and 12.00 mg/mL), the essential oils did not show antiviral activity against coxsakievirus B3.Conclusion: The essential oils obtained from Hypericum triquetrifolium can be used as antimicrobial agents and could be safe at non cytotoxic doses. As shown for the tested essential oils, comparative analysis need to be undertaken to better characterize also the antimicrobial activities of Hypericum triquetrifolium extracts with different solvents as well as their purified fractions and their pure secondary metabolites. © 2013 Rouis et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Rouis, Zyed
Tunisia, Monastir
Université de Monastir
Abid, Nabil Ben Salem
Tunisia, Monastir
Université de Monastir
Koudja, Sadok
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Yangui, Thabèt
Tunisia, Sfax
Centre de Biotechnologie de Sfax
Elaissi, Ameur
Tunisia, Monastir
Université de Monastir
Cioni, Pier Luigi
Italy, Pisa
Università Di Pisa
Flamini, Guido
Italy, Pisa
Università Di Pisa
Aouni, Mahjoub
Tunisia, Monastir
Université de Monastir
Statistics
Citations: 39
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1186/1472-6882-13-24
e-ISSN:
14726882
Study Locations
Tunisia