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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro
Phytotherapy Research, Volume 24, No. 10, Year 2010
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Description
The extracts and 12 sesquiterpenes obtained from the East African medicinal plant Warburgia ugandensis Sprague (Canellaceae) were assessed for their antiplasmodial activity against the chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum and antitrypanosomal activity against Trypanosoma brucei rhodesiense. The dichloromethane extract displayed strong antiplasmodial and antitrypanosomal activities with IC 50 values of 8.10 and 1.10 μg/mL against K1 strain of the malaria parasite and STlB900 strain of T. b. rhodesiense, respectively. Among the compounds evaluated for inhibition of trypomastigotes, both drimane and coloratane sesquiterpenes possessing aldehyde groups at positions 8 and 9 were found to show most antitrypanosomal activity with IC50 values in the range 0.56-6.4 μM. The antiplasmodial assays also revealed that the six coloratane and six drimane sesquiterpenes isolated from this extract exhibited significant antitrypanosomal activity with IC50 values ranged from 0.45 to ?114 μM. Among the compounds tested against the malarial parasite P. falciparum 11?-hydroxymuzigadiolide (3) was most active with an IC50 value of 6.40 μM. © 2010 John Wiley & Sons, Ltd.
Authors & Co-Authors
Wube, Abraham Abebe
Unknown Affiliation
Bucar, Franz
Unknown Affiliation
Gibbons, Simon
Unknown Affiliation
Asres, Kaleab
Unknown Affiliation
Rattray, Lauren
Unknown Affiliation
Croft, S. L.
Unknown Affiliation
Statistics
Citations: 44
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1002/ptr.3126
ISSN:
0951418X
e-ISSN:
10991573
Research Areas
Infectious Diseases