Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Multimodal voxel-based meta-analysis of white matter abnormalities in obsessive-compulsive disorder
Neuropsychopharmacology, Volume 39, No. 7, Year 2014
Notification
URL copied to clipboard!
Description
White matter (WM) abnormalities have long been suspected in obsessive-compulsive disorder (OCD) but the available evidence has been inconsistent. We conducted the first multimodal meta-analysis of WM volume (WMV) and fractional anisotropy (FA) studies in OCD. All voxel-wise studies comparing WMV or FA between patients with OCD and healthy controls in the PubMed, ScienceDirect, Google Scholar, Web of Knowledge and Scopus databases were retrieved. Manual searches were also conducted and authors were contacted soliciting additional data. Thirty-four data sets were identified, of which 22 met inclusion criteria (five of them unpublished; comprising 537 adult and pediatric patients with OCD and 575 matched healthy controls). Whenever possible, raw statistical parametric maps were also obtained from the authors. Peak and raw WMV and FA data were combined using novel multimodal meta-analytic methods implemented in effect-size signed differential mapping. Patients with OCD showed widespread WM abnormalities, but findings were particularly robust in the anterior midline tracts (crossing between anterior parts of cingulum bundle and body of corpus callosum), which showed both increased WMV and decreased FA, possibly suggesting an increase of fiber crossing in these regions. This finding was also observed when the analysis was limited to adult participants, and especially pronounced in samples with a higher proportion of medicated patients. Therefore, patients with OCD may have widespread WM abnormalities, particularly evident in anterior midline tracts, although these changes might be, at least in part, attributable to the effects of therapeutic drugs. © 2014 American College of Neuropsychopharmacology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4023155/bin/npp20145x1.pdf
Authors & Co-Authors
Radua, Joaquim
United Kingdom, London
King's College London
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Grau, Mar
United Kingdom, London
King's College London
United Kingdom, London
Early Intervention in Psychosis Team
Van Den Heuvel, Odile A.
Netherlands, Amsterdam
Amsterdam Umc - Vrije Universiteit Amsterdam
Thiebaut De Schotten, Michel
United Kingdom, London
King's College London
France, Paris
Cnrs Centre National de la Recherche Scientifique
Stein, Dan J.
South Africa, Cape Town
Faculty of Health Sciences
Canales-Rodríguez, Erick Jorge
Spain, Madrid
Centro de Investigación Biomédica en Red de Salud Mental
Catani, Marco
United Kingdom, London
King's College London
Mataix-Cols, David
United Kingdom, London
King's College London
Sweden, Stockholm
Karolinska Institutet
Statistics
Citations: 141
Authors: 8
Affiliations: 7
Identifiers
Doi:
10.1038/npp.2014.5
ISSN:
0893133X
e-ISSN:
1740634X
Study Approach
Systematic review