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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Neural tube defects are rare among black Americans but not in sub-Saharan black Africans: The case of Yaounde - Cameroon
Journal of the Neurological Sciences, Volume 270, No. 1-2, Year 2008
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Description
Background: Neural tube defects (NTD) are complex malformations rare in black Americans and Japanese. The incidence related to births or community based studies have not been published in Cameroon or in black sub-Saharan countries, except one study in the Nigerian middle belt [A. Courtney, Adolfo Correa Rowland, Janet D. Cragan and Alverson J. Clinton, Are encephalocede neural tube defects? Official journal of the American Academy of paediatrics 2006; (13): 1-10.]. Methods: To evaluate the incidence of neural tube defects in Yaounde, the birth record of the maternities was retrospectively exploited during the last ten years period (1997-2006). Results: A total of 52,710 births were recorded in the 03 main hospitals of Yaounde. Ninety eight (98) cases of NTD with an incidence of 1.99 cases per 1000 births were registered. Spina bifida cystica (myelomeningocele, meningocele) represented 71%, followed by encephalocele (21.1%) and anencephaly (5.4%). Periconceptional folic acid was not taken by any of the mothers in our study. Abortion of affected pregnancies is illegal in Cameroon. Conclusion: Neural Tube Defects may not be so rare in sub-Saharan black Africans particularly in Yaounde (Cameroon). Spina bifida is the most frequent malformation. The results of this study make a case for periconceptional folic acid supplementation in our communities. The respective contributions of racial (genetic) versus environmental (or nutritional) factors will however have to be studied in order to develop a comprehensive prevention strategy. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Njamnshi, Alfred Kongnyu
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Djientcheu, Vincent De Paul
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Lekoubou, Alain L.
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Guemse, Mohamadou
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Obama, Marie Thérèse Abena Ondoa
Cameroon
University Hospital Center of Yaounde
Mbu, Robinson Enow
Cameroon, Yaounde
Central Hospital of Yaounde Fmbs
Takongmo, Samuel
Cameroon
University Hospital Center of Yaounde
Kago, Innocent
Cameroon
The Chantal Biya Foundation Yaounde
Statistics
Citations: 45
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1016/j.jns.2008.01.010
ISSN:
0022510X
Research Areas
Genetics And Genomics
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Cameroon