Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The effect of a single injection of cytosine arabinoside on cell population kinetics in the mouse jejunal crypt
Virchows Archiv B Cell Pathology Including Molecular Pathology, Volume 34, No. 1, Year 1980
Notification
URL copied to clipboard!
Description
The early effects of a single injection of cytosine arabinoside (ara-C) on cell population kinetics in the jejunal crypt of the mouse were studied using autoradiography with tritiated thymidine, and metaphase arrest with vincristine. Ara-C had three main effects on crypt cells: a block of cells near the transition from G1 to S, death of nearly all cells in S, and a temporary block of the survivors, which remained viable and were able to proceed through the cell cycle. Throughout the crypt there was a decrease in cell cycle time and an increase in growth fraction. Although changes in proliferative rate were highest in the lowest part of the crypt it was not possible to show that crypt repopulation originated only from basal crypt cells, and the data are consistent with repopulation from the faster cycling cells in the proliferative compartment. © 1980 Springer-Verlag.
Authors & Co-Authors
Al-Dewachi, Huthaifa S.
Iraq, Mosul
University of Mosul
Wright, Nicholas A.W.
United Kingdom, Oxford
University of Oxford
Appleton, David R.
United Kingdom, Newcastle
Newcastle University
Watson, Alexander J.
United Kingdom, Newcastle
Newcastle University
Statistics
Citations: 27
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1007/BF02892427
ISSN:
00426431
Study Design
Cross Sectional Study