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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of flash-heat treatment on immunoglobulins in breast milk
Journal of Acquired Immune Deficiency Syndromes, Volume 51, No. 3, Year 2009
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Description
BACKGROUND: Heat-treated expressed breast milk is recommended by the World Health Organization as an option to reduce vertical HIV transmission in resource-poor regions. Flash-heat (FH) is a low technology pasteurization method developed for home use, but its effect on quantity and quality of breast milk immunoglobulins is unknown. OBJECTIVE: To evaluate FH's effect on breast milk immunoglobulin levels and antigen-binding capacity. DESIGN/METHODS: Fifty HIV+ mothers in South Africa provided breast milk. Part of each sample served as an unheated control; the remainder was flash-heated. Total and antigen-specific immunoglobulin A (IgA) and immunoglobulin G (IgG) were measured by enzyme-linked immunosorbent assay. Paired t test was performed on log-transformed data. RESULTS: FH significantly decreased total IgA and IgG concentrations [geometric mean (geometric SD) 318.0 (1.9) vs. 398.2 (1.9) μg/mL and 89.1 (2.7) vs. 133.3 (2.5) μg/mL, P < 0.001 each]. Similar decreases in antiĝ€"HIV-1 gp120 IgG, antiĝ€"pneumococcal polysaccharide, and antiĝ€"poliovirus IgA occurred (P < 0.001 each). Although the latter was most affected, FH retained 66% of the antigen-binding ability. In contrast, binding capacity of IgA and IgG to influenza increased after FH (P = 0.029 and 0.025, respectively). CONCLUSIONS: Most breast milk immunoglobulin activity survives FH, suggesting flash-heated breast milk is immunologically superior to breast milk substitutes. Clinical significance of this decreased immunoglobulin activity needs evaluation in prospective trials. © 2009 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Chantry, C.
United States, Sacramento
Uc Davis Medical Center
United States, Davis
University of California, Davis
Israel-Ballard, Kiersten A.
United States, Sacramento
Uc Davis Medical Center
Moldoveanu, Zina
United States, Birmingham
The University of Alabama at Birmingham
Peerson, Janet M.
United States, Davis
University of California, Davis
Coutsoudis, Anna
South Africa, Durban
The Nelson R. Mandela Medical School
Sibeko, Lindiwe N.
Canada, Montreal
Université Mcgill
Abrams, B.
United States, Berkeley
University of California, Berkeley
Statistics
Citations: 43
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1097/QAI.0b013e3181aa12f2
ISSN:
15254135
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
South Africa