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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Addition of carvedilol to University Wisconsin solution improves rat steatotic and nonsteatotic liver preservation
Liver Transplantation, Volume 16, No. 2, Year 2010
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Description
Here we examine the effect of adding carvedilol (CVD) to University of Wisconsin (UW) solution on the preservation of steatotic and nonsteatotic livers during cold ischemia and after normothermic reperfusion. We used an isolated perfused rat liver model. The following protocols were evaluated. Protocol 1 concerned the effect of CVD after cold ischemia. Steatotic and nonsteatotic livers were preserved for 24 hours in UW solution alone or with CVD. Livers without cold ischemia were used as controls. Transaminases were evaluated in the flushing effluent. Protocol 2 involved the effect of CVD after reperfusion. Both liver types were preserved for 24 hours in UW solution alone or with CVD and then perfused ex vivo for 2 hours at 37°C. Livers flushed and perfused without ischemia were used as controls. Hepatic injury and functionality [transaminases, bile production, and hepatic clearance of sulfobromophthalein (BSP)] were evaluated after reperfusion. In addition, factors potentially involved in hepatic ischemia-reperfusion injury, including oxidative stress (malondialdehyde and superoxide anion levels), mitochondrial damage (glutamate dehydrogenase activity), microcirculatory disorders (flow rate and vascular resistance), and adenosine triphosphate (ATP) depletion, were evaluated after reperfusion. After cold ischemia, steatotic livers preserved in UW solution showed higher transaminase levels than nonsteatotic livers. After reperfusion, steatotic livers preserved in UW solution showed higher transaminase levels and lower bile production and BSP clearance than nonsteatotic livers. Alterations in the perfusion flow rate and vascular resistance, mitochondrial damage, and reduced ATP content were more evident in steatotic livers preserved in UW solution. The addition of CVD to UW solution reduced hepatic injury, obstructed its mechanisms, and improved hepatic functionality in both liver types. We conclude that CVD is a useful additive for UW solution that improves the preservation of steatotic and nonsteatotic livers subjected to prolonged cold ischemia. © 2010 AASLD.
Authors & Co-Authors
Mosbah, Ismail Ben
Unknown Affiliation
Roselĺo-Catafau, Joan
Spain, Barcelona
Csic - Instituto de Investigaciones Biomedicas de Barcelona Iibb
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Spain, Madrid
Instituto de Salud Carlos Iii
Alfany-Fernandez, Izabel
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Rimola, Antoni
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Barcelona
Hospital Clinic Barcelona
Parellada, Pera Puig
Spain, Barcelona
Faculty of Medicine
Mitjavila, Maria Teresa
Spain, Barcelona
Universitat de Barcelona
Lojek, Antonin
Czech Republic, Brno
Institute of Biophysics of the Academy of Sciences of the Czech Republic
Ben Abdennebi, Hassen
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Boillot, Olivier C.
France, Lyon
Hopital Edouard Herriot
Rodés, Juan M.
Spain, Madrid
Instituto de Salud Carlos Iii
Spain, Barcelona
Hospital Clinic Barcelona
Peralta, Carmen
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Spain, Madrid
Instituto de Salud Carlos Iii
Statistics
Citations: 43
Authors: 11
Affiliations: 9
Identifiers
Doi:
10.1002/lt.21968
ISSN:
15276465
e-ISSN:
15276473
Research Areas
Noncommunicable Diseases
Violence And Injury