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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Long-term results of stereotactic proton beam radiotherapy for acoustic neuromas
Radiotherapy and Oncology, Volume 90, No. 2, Year 2009
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Description
Background and purpose: A retrospective study evaluating the role of hypofractionated stereotactic proton beam therapy for acoustic neuromas. Materials and methods: The data of 51 patients treated with hypofractionation (3 fractions) and followed up for a minimum of 2 years, were analyzed. Mean dose prescribed to ICRU reference point (isocenter) was 26 cobalt gray equivalent (CGyE) in 3 fractions. Mean minimum tumor dose was 21.4 CGyE/3. Cranial nerve functions were evaluated clinically. Serial MR Scans were used to evaluate local control. Results: With a mean clinical and radiological follow-up of 72 and 60 months respectively, the 5-year results showed a 98% local control, with a hearing preservation of 42%, a facial nerve preservation of 90.5% and a trigeminal nerve preservation of 93%. Conclusion: For those patients harboring large acoustic neuromas that are inoperable, hypofractionated stereotactic proton beam offers long-term control with minimal side-effects. © 2008 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Vernimmen, Frederik Jozef Alfons Ivan
South Africa, Tygerberg
Tygerberg Hospital
Mohamed, Zainab
South Africa, Somerset West
Medical Radiation Group
Slabbert, Jacobus P.S.
South Africa, Somerset West
Radiation Biophysics
Wilson, Jennifer A.G.
South Africa, Pretoria
Steve Biko Academic Hospital
Statistics
Citations: 57
Authors: 4
Affiliations: 4
Identifiers
Doi:
10.1016/j.radonc.2008.11.004
Research Areas
Cancer
Study Design
Cohort Study