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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
The wheat MAP kinase phosphatase 1 confers higher lithium tolerance in yeast
FEMS Yeast Research, Volume 12, No. 7, Year 2012
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Description
The durum wheat TMKP1 gene encodes a MAP kinase phosphatase. When overexpressed in Saccharomyces cerevisiae, TMKP1 leads to salt stress tolerance (especially LiCl), which is dependent on the phosphatase activity of the protein. The TMKP1-associated Li+ resistance is restricted to a galactose-containing medium. Interestingly, this salt tolerance is abolished in the absence of one member of the yeast type 2C Ser/Thr protein phosphatase family (Ptc1) but not when other members such as Ptc2 or Ptc3 are lacking. Increased Li+ tolerance is not mediated by regulation of the P-type ATPase Ena1, a major determinant for salt tolerance. In contrast, the effect of TMKP1 depends on Hal3 (a negative regulator of Ppz phosphatases) and on the presence of the high-affinity potassium transporters Trk1/Trk2. Tolerance to Li+ is also abolished in cells lacking the aldose reductase Gre3, previously shown to be involved in the resistance to this cation. This study provides evidence that the wheat TMKP1 phosphatase is contributing to reduce the exacerbated lithium toxicity in galactose-grown cells, in a way that depends on the presence of the potassium Trk transporters. © 2012 Federation of European Microbiological Societies.
Authors & Co-Authors
Zaïdi, Ikram
Tunisia, Sfax
University of Sfax
González, Asier
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Touzri, Majdi
Tunisia, Sfax
University of Sfax
Álvarez, María Concepción
Spain, Cordoba
Universidad de Córdoba
Ramos, José J.A.
Spain, Cordoba
Universidad de Córdoba
Masmoudi, Khaled
Tunisia, Sfax
University of Sfax
Ariño, Joaquín
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Hanin, Moez
Tunisia, Sfax
University of Sfax
Statistics
Citations: 10
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1111/j.1567-1364.2012.00827.x
ISSN:
15671356
e-ISSN:
15671364
Research Areas
Genetics And Genomics