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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Remittent non-destructive polysynovitis in P-ANCA-positive vasculitis patients with anti-CCP antibodies
Joint Bone Spine, Volume 77, No. 6, Year 2010
Notification
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Description
Patients with antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis (AASV) commonly suffer from arthralgias and, sometimes, polyarthritis during disease flares. Although rheumatoid factor (RF) can be detected in up to 37-50% of AASV patients, anti-cyclic citrullinated peptide (anti-CCP) antibodies are rare. Herein, we describe the clinical features of five P-ANCA-positive vasculitis patients, who had persistent and/or high anti-CCP levels and, more importantly, suffered from remittent non-destructive arthralgias and polysynovitis, independently of the vasculitis course and without evidence of RA. Two were initially thought to have RA rather than microscopic polyangiitis and, at AASV diagnosis, all had kidney involvement and three had alveolar hemorrhages. With a median follow-up of 30 months, one suffered vasculitis relapses, preceded by polysynovitis, and others had remittent arthralgias and polysynovitis, while their vasculitides remained in remission. None of these patients had radiological destructive arthritis. We discuss the challenge of diagnosing these patients positive for anti-CCP and ANCA, and with dominant articular manifestations. AASV patients with anti-CCP antibodies may experience relapsing polysynovitis and non-erosive polyarthritis prior to vasculitis flares, but also independently of the vasculitis course, which is uncommon in AASV, and might represent a small subgroup of AASV patients. © 2010 Société française de rhumatologie.
Authors & Co-Authors
Pagnoux, Christian
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Seror, Raphaele
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Bérézné, Alice
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Rouabhia, Samir
Algeria, Batna
Centre Hospitalo-universitaire Touhami Benflis - Batna
Goulvestre, Claire
France, Paris
Hopital Cochin Ap-hp
Guillevin, Loïc I.
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
Statistics
Citations: 9
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1016/j.jbspin.2010.02.013
ISSN:
1297319X
Study Design
Cohort Study