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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Placental malaria increases malaria risk in the first 30 months of life
Clinical Infectious Diseases, Volume 47, No. 8, Year 2008
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Description
Background. Plasmodium falciparum infection during pregnancy is associated with stillbirth, fetal growth restriction, and low birth weight. An additional consequence may be increased risk of malaria in early life, although the epidemiological evidence of this consequence is limited. Methods. A cohort of 527 children were observed actively every month for 30 months after delivery. Offspring of mothers with microscopically detectable placental P. falciparum infection at the time of delivery were defined as exposed. The outcome measure was malaria (parasitemia and fever). Analyses were performed using Cox proportional hazard models and were stratified by gravidity. Results. Overall, offspring of mothers with placental P. falciparum infection had a significantly higher risk of clinical malaria during the first 30 months of life (adjusted hazard ratio, 2.1; 95% confidence interval [CI], 1.2-3.7). The adjusted hazard ratio for offspring of multigravidae was 2.6 (95% CI, 1.3-5.3), and that for primigravidae was 1.5 (95% CI, 0.6-3.8). The offspring of placenta-infected primigravidae had no episodes of malaria during the first year of life. Conclusions. Our findings show that active placental P. falciparum infection detected at delivery is associated with an ∼2-fold greater risk of malaria during early life, compared with noninfection. The fact that persons born to infected multigravidae rather than primigravidae appear to be at greater risk emphasizes the importance of preventing malaria in mothers of all gravidities. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Schwarz, Norbert Georg
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Adégnika, Ayôla Akim
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Netherlands, Leiden
Leids Universitair Medisch Centrum
Breitling, Lutz Ph
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabor, Julian Justin
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Agnandji, Sélidji Todagbe M.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Newman, Robert David
United States, Atlanta
Centers for Disease Control and Prevention
Lell, Bertrand
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Issifou, Saadou
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Yazdanbakhsh, Maria M.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Netherlands, Leiden
Leids Universitair Medisch Centrum
Luty, A. J.F.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Netherlands, Nijmegen
Radboud University Medical Center
Kremsner, Peter G.
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Grobusch, Martín Peter
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
South Africa, Johannesburg
University of the Witwatersrand
South Africa, Johannesburg
School of Pathology
South Africa, Johannesburg
National Health Laboratory Service
Statistics
Citations: 137
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1086/591968
ISSN:
10584838
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study