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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Specific antibody responses against membrane proteins of erythrocytes infected by Plasmodium falciparum of individuals briefly exposed to malaria
Malaria Journal, Volume 9, No. 1, Article 276, Year 2010
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Description
Background. Plasmodium falciparum infections could lead to severe malaria, principally in non-immune individuals as children and travellers from countries exempted of malaria. Severe malaria is often associated with the sequestration of P. falciparum-infected erythrocytes in deep micro-vascular beds via interactions between host endothelial receptors and parasite ligands expressed on the surface of the infected erythrocyte. Although, serological responses from individuals living in endemic areas against proteins expressed at surface of the infected erythrocyte have been largely studied, seldom data are available about the specific targets of antibody response from travellers. Methods. In order to characterize antigens recognized by traveller sera, a comparison of IgG immune response against membrane protein extracts from uninfected and P. falciparum-infected red blood cells (iRBC), using immunoblots, was performed between non exposed individuals (n = 31) and briefly exposed individuals (BEI) (n = 38) to malaria transmission. Results. Immune profile analysis indicated that eight protein bands from iRBC were significantly detected more frequently in the BEI group. Some of these antigenic proteins were identified by an original immuno-proteomic approach. Conclusion. Collectively, these data may be useful to characterize the singular serological immune response against a primary malaria infection in individuals briefly exposed to transmission. © 2010 Fontaine et al; licensee BioMed Central Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2959075/bin/1475-2875-9-276-S1.DOC
https://efashare.b-cdn.net/share/pmc/articles/PMC2959075/bin/1475-2875-9-276-S2.DOC
https://efashare.b-cdn.net/share/pmc/articles/PMC2959075/bin/1475-2875-9-276-S3.PNG
Authors & Co-Authors
Fontaine, Albin
France, Bretigny-sur-orge
Institut de Recherche Biomédicale Des Armées
Pophillat, Matthieu
France, Marseille
Centre D’immunologie de Marseille-luminy
Villard, Claude
France, Marseille
Aix Marseille Université
Belghazi, Maya
France, Marseille
Aix Marseille Université
Fourquet, Patrick
France, Marseille
Centre D’immunologie de Marseille-luminy
Lefranc, Didier
France, Lille
Université de Lille
Rogier, Christophe
France, Bretigny-sur-orge
Institut de Recherche Biomédicale Des Armées
Fusaï, Thierry
France, Bretigny-sur-orge
Institut de Recherche Biomédicale Des Armées
Statistics
Citations: 23
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1186/1475-2875-9-276
ISSN:
14752875
Research Areas
Infectious Diseases
Maternal And Child Health