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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Amaryllidaceae alkaloids belonging to different structural subgroups display activity against apoptosis-resistant cancer cells
Journal of Natural Products, Volume 73, No. 7, Year 2010
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Description
Fifteen Amaryllidaceae alkaloids (1-15) were evaluated for their antiproliferative activities against six distinct cancer cell lines. Several of these natural products were found to have low micromolar antiproliferative potencies. The log P values of these compounds did not influence their observed activity. When active, the compounds displayed cytostatic, not cytotoxic activity, with the exception of pseudolycorine (3), which exhibited cytotoxic profiles. The active compounds showed similar efficacies toward cancer cells irrespective of whether the cell lines were responsive or resistant to proapoptotic stimuli. Altogether, the data from the present study revealed that lycorine (1), amarbellisine (6), haemanthamine (14), and haemanthidine (15) are potentially useful chemical scaffolds to generate further compounds to combat cancers associated with poor prognoses, especially those naturally resistant to apoptosis, such as glioblastoma, melanoma, non-small-cell lung, and metastatic cancers. © 2010 The American Chemical Society and American Society of Pharmacognosy.
Authors & Co-Authors
Van Goietsenoven, Gwendoline
Belgium, Brussels
Université Libre de Bruxelles
Andolfi, Anna
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Lallemand, Benjamin
Belgium, Brussels
Université Libre de Bruxelles
Cimmino, Alessio
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Lamoral-Theys, Delphine
Belgium, Brussels
Université Libre de Bruxelles
Gras, Thierry
Belgium, Brussels
Université Libre de Bruxelles
Abou-Donia, Amina H.A.
Egypt, Alexandria
Alexandria University
Dubois, Jacques G.
Belgium, Brussels
Université Libre de Bruxelles
Lefranc, Florence
Belgium, Brussels
Université Libre de Bruxelles
Mathieu, Véronique
Belgium, Brussels
Université Libre de Bruxelles
Kornienko, Alexander V.
United States, Socorro
New Mexico Institute of Mining and Technology
Kiss, Robert
Belgium, Brussels
Université Libre de Bruxelles
Evidente, Antonio
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Statistics
Citations: 128
Authors: 13
Affiliations: 4
Identifiers
Doi:
10.1021/np9008255
ISSN:
01633864
e-ISSN:
15206025
Research Areas
Cancer