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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
An investigation to assess the potential of CD25
high
CD4
+
T cells to regulate responses to donor alloantigens in clinically stable renal transplant recipients
Transplant International, Volume 21, No. 1, Year 2008
Notification
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Description
Regulatory T cells are enriched within CD25highCD4+ leukocytes, however their role in renal transplant recipients with stable function vs. recipients with biopsy-proven chronic allograft dysfunction remains unclear. We therefore studied the number, phenotype, and function of CD25 highCD4+ cells in the peripheral blood of 30 renal transplant recipients of living-related grafts, comprising 15 rejection-free recipients with stable graft function (Group A) and 15 with biopsy-proven chronic graft dysfunction (Group B). A higher absolute number of CD25 highCD4+ cells were present in the peripheral blood of rejection-free recipients (Group A) vs. those recipients with chronic graft dysfunction (Group B) (P = 0.019); but there was no significant difference with healthy volunteers (P = 0.084). In carboxyfluorescein diacetate succinimidyl ester-mixed leukocyte culture assays, depletion of CD25highCD4 + revealed active regulation in 11 (74%) of 15 rejection-free recipient samples (Group A) in response to donor- but not third party-leukocytes, whereas no regulatory activity was observed in any samples from recipients with chronic graft dysfunction (Group B). In conclusion, these data provide evidence for the presence of an increased number of CD25 highCD4+ T cells with donor-specific regulatory activity in the peripheral blood of renal transplant recipients with stable graft function compared with recipients with chronic graft dysfunction. © 2007 The Authors.
Authors & Co-Authors
Akl, Ahmed Ibrahim
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Jones, Nicholas D.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
Rogers, Nichola
United Kingdom, Oxford
University of Oxford Medical Sciences Division
United Kingdom, London
Hammersmith Hospital
Bakr, Mohamed Adel
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Mostafa, Amani
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
El Shehawy, El Metwaly
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Ghoneim, Mohamed A.
Egypt, Mansoura
Mansoura University, Urology and Nephrology Center
Wood, Kathryn J.
United Kingdom, Oxford
University of Oxford Medical Sciences Division
United Kingdom, Oxford
John Radcliffe Hospital
Statistics
Citations: 54
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1111/j.1432-2277.2007.00560.x
ISSN:
09340874
e-ISSN:
14322277