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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Plasmodium falciparum malaria and perinatally acquired human immunodeficiency virus type 1 infection in kinshasa, zaire: A prospective, longitudinal cohort study of 587 children
New England Journal of Medicine, Volume 325, No. 2, Year 1991
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Description
Background. It is uncertain whether Plasmodium falciparum malaria is more frequent or more severe in children with perinatally acquired human immunodeficiency virus type 1 (HIV-1) infection and whether P. falciparum infection accelerates the progression of HIV-related disease. Methods. We conducted a prospective, longitudinal cohort study in Kinshasa, Zaire. Two hundred sixty children 5 to 9 months of age who had been born to HIV-1—seropositive mothers and 327 children of the same age who had been born to seronegative mothers were monitored intensively for malaria over a 13-month period. All episodes of fever were evaluated with blood smears for malaria, and children found to be infected with P. falciparum were treated with a standard regimen of oral quinine. Results. A total of 2899 fevers were evaluated, with 271 cases of malaria identified. No statistically significant differences were found in the incidence, severity, or response to therapy of malaria among four well-defined groups of children: those with the acquired immunodeficiency syndrome (AIDS), those who were HIV-1—seropositive throughout the study, those who were born to HIV-1—seropositive mothers but reverted to seronegative, and those who were seronegative throughout the study. During the 13-month period the incidence of malaria in the 36 children with HIV infection in whom AIDS developed was lower, although not significantly so, than in the 37 in whom AIDS did not develop. Conclusions. In this study malaria was not more frequent or more severe in children with progressive HIV-1 infection and malaria did not appear to accelerate the rate of progression of HIV-1 disease. (N Engl J Med 1991; 325:105–9.). © 1991, Massachusetts Medical Society. All rights reserved.
Authors & Co-Authors
Greenberg, Alan E.
United States, Atlanta
National Center for Infectious Diseases
Nsa, Wato
Congo, Kinshasa
Projet Sida
Ryder, Robert W.
Congo, Kinshasa
Projet Sida
United States, Atlanta
National Center for Infectious Diseases
Medi, Mvula
Congo, Kinshasa
Projet Sida
Nzeza, Matadi
Congo, Kinshasa
Projet Sida
Kitadi, Nsimba
Congo, Kinshasa
Projet Sida
Baangi, Matela
Congo, Kinshasa
Projet Sida
Malanda, Nsuami
Congo, Kinshasa
Projet Sida
Hassig, Susan E.
Congo, Kinshasa
Projet Sida
Davachi, Farzin
Congo, Kinshasa
Mama Yemo Hospital
Statistics
Citations: 123
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1056/NEJM199107113250206
ISSN:
00284793
e-ISSN:
15334406
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative