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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Lactate signalling regulates fungal β-glucan masking and immune evasion
Nature Microbiology, Volume 2, Article 16238, Year 2016
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Description
As they proliferate, fungi expose antigens at their cell surface that are potent stimulators of the innate immune response, and yet the commensal fungus Candida albicans is able to colonize immuno competent individuals. We show that C. albicans may evade immune detection by presenting a moving immunological target. We report that the exposure of β-glucan, a key pathogen-associated molecular pattern (PAMP) located at the cell surface of C. albicans and other pathogenic Candida species, is modulated in response to changes in the carbon source. Exposure to lactate induces β-glucan masking in C. albicans via a signalling pathway that has recruited an evolutionarily conserved receptor (Gpr1) and transcriptional factor (Crz1) from other well-characterized pathways. In response to lactate, these regulators control the expression of cell-wall-related genes that contribute to β-glucan masking. This represents the first description of active PAMP masking by a Candida species, a process that reduces the visibility of the fungus to the immune system. © 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Authors & Co-Authors
Ballou, Elizabeth Ripley
United Kingdom, Aberdeen
University of Aberdeen
Walker, Louise A.
United Kingdom, Aberdeen
University of Aberdeen
Erwig, Lars Peter
United Kingdom, Aberdeen
University of Aberdeen
Munro, Carol A.
United Kingdom, Aberdeen
University of Aberdeen
Gow, Neil A.R.
United Kingdom, Aberdeen
University of Aberdeen
Brown, Gordon D.A.
United Kingdom, Aberdeen
University of Aberdeen
MacCallum, Donna M.
United Kingdom, Aberdeen
University of Aberdeen
Brown, Alistair J.P.
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 169
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1038/nmicrobiol.2016.238
ISSN:
20585276
Research Areas
Environmental