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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Serial transmission of spongiocytic hepatitis to woodchucks (possible association with a specific delta strain)
Journal of Hepatology, Volume 22, No. 4, Year 1995
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Description
Background/Aims: Outbreaks of severe hepatitis have been reported from Africa and South America. Description of the case has shown the histological hallmark to be the presence of ballooning hepatocytes with fat drops surrounding the nucleus (spongiocytes or morula cells). Methods: Experimental reproduction of this syndrome for the verification of a possible role of a specific HDV strain was performed by the inoculation of serum and liver extracts from African patients (Bangui-Central African Republic), who died with this syndrome, into American woodchuck carriers of WHV (WC 231,144), the results of which were then compared with animals inoculated with a reference wild HDV strain (WC 300,173,154), and those which received material from a European fulminant HDV case (WC 88,93). Results: Following the initial inoculation, the animals receiving African inocula had a delayed anti-HDV seroconversion, high mortality and showed the presence of spongiocytes, while the other animals had a classical evolution of HDV superinfection in woodchucks. Furthermore, the African inocula caused less inhibition of WHV replication, as well as a predominant cytoplasmic expression of HDAg, in contrast to the animals which received the other inocula. The second passage experiments gave similar results. Conclusions: We conclude that this peculiar form of HDV fulminant hepatitis can be experimentally reproduced and might be specifically related to a more pathogenic strain. © 1995.
Authors & Co-Authors
Paraná, Raymundo
Brazil
University Hospital of Bahia
Gerard, Françoise
France, Paris
Institut Pasteur, Paris
Lesbordes, Jean Louis
Central African Republic
National Hospital of Bangui
Pichoud, Christian
France, Paris
Inserm
Vitvitski, Ludiviila
France, Paris
Inserm
Costa Lyra, Luiz Guilherme
Brazil
University Hospital of Bahia
Trépo, Christian R.
France, Paris
Inserm
Statistics
Citations: 15
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.1016/0168-8278(95)80111-1
ISSN:
01688278
Research Areas
Infectious Diseases
Study Locations
Central African Republic