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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Genotoxicity and endocrine-disruption potentials of sediment near an oil spill site: Two years after the hebei spirit oil spill
Environmental Science and Technology, Volume 45, No. 17, Year 2011
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Description
The Hebei Spirit oil spill episode (December 7, 2007) has affected the western coastal area of South Korea; however, there is limited information on the potential toxicity of the oil spill to the ecosystem or humans. The potential toxicity of sediments collected from the affected area (n = 22) 2 years after the spill was evaluated. Acute lethal toxicity tests using Vibrio fischeri and Moina macrocopa and tests for genotoxicity and alteration of steroidogenesis using chicken DT40 cells and H295R cells, respectively, were conducted. Both crude and weathered oil extracts were evaluated in order to link the observed toxicity in the sediment extracts to the oil spill. Whereas toxicity to bacteria and daphnids was observed in only two elutriate samples, 10 of the 22 sediment extracts showed genotoxic potential in DT40 cells. The mechanisms of genotoxicity involved nucleotide excision repair (XPA -/), homologous recombination (RAD54 -/-), and translesion synthesis pathways (REV3 -/-). In addition, nine sediment extracts caused significantly greater production of E2 in H295R cells, and significant up-regulation of CYP19, CYP11B2, and 3βHSD2 by sediment extracts was observed. The pattern of toxicities observed in both crude and weathered oil samples was similar to that observed in the sediment extracts. The genotoxicicity and endocrine-disruption potential of the sediment extracts suggest a need for long-term followup for such toxicity in humans and wildlife in this area. © 2011 American Chemical Society.
Authors & Co-Authors
Ji, Kyunghee
Unknown Affiliation
Seo, Jihyeon
Unknown Affiliation
Liu, Xiaoshan
Unknown Affiliation
Lee, Jin Young
Unknown Affiliation
Lee, Sangwoo
Unknown Affiliation
Lee, Woojin
Unknown Affiliation
Park, Jeongim
Unknown Affiliation
Khim, Jong-Seong Seong Jskocean@snu Ac Kr
Unknown Affiliation
Hong, Seongjin
Unknown Affiliation
Choi, Yeyong
Unknown Affiliation
Shim, Won Joon
Unknown Affiliation
Takeda, Shiunichi
Unknown Affiliation
Giesy, John P.
Unknown Affiliation
Choi, Kyungho
Unknown Affiliation
Statistics
Citations: 61
Authors: 14
Affiliations: 11
Identifiers
Doi:
10.1021/es200724x
ISSN:
0013936X
e-ISSN:
15205851