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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Can paraoxonase 1 polymorphisms (L55 M and Q192 R) protect children with type 1 diabetes against lipid abnormalities?
Journal of Clinical Lipidology, Volume 8, No. 3, Year 2014
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Description
Background Only a few studies have focused on the possible modulatory role of paraoxonase 1 (PON1) polymorphisms in lipid profiles, especially in children and in adolescents with type 1 diabetes (T1D). Objective We propose to study the association between PON1 polymorphisms (PON1-55 and PON1-192) and a lipid profile in a young Tunisian population with T1D. Methods The study compared 122 children and adolescents with T1D with 97 controls. Genomic DNA was collected from 116 patients and 91 controls. Lipid parameters were determined by automated methods. PON1 activity was measured by a spectrophotometric method and genotyping of the PON1 gene was assessed by multiplex polymerase chain reaction followed by restriction fragment-length polymorphism. Results A significant increase in total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B (ApoB), and lipoprotein (a) (Lp(a)) and a significant decrease in apolipoprotein A1 (ApoA1), ApoA1/ApoB ratio, and PON1 activity/HDL-C ratio were observed in children with T1D compared with controls. In the LLQR haplotype, the group with diabetes showed significantly higher values of total cholesterol, LDL-C, apoB, Lp(a), and apoA1/apoB ratio compared with the control group. Those with diabetes with the LLQQ haplotype showed a significant decrease in LDL-C and Lp(a) compared with controls (P <.0001). Conclusion PON1 polymorphisms (PON1-55 and PON1-192) seem to be involved in the altering the lipid profile in T1D. The LLQR haplotype provided an atherogenic lipid profile in children with T1D compared with controls. LLQQ haplotype seemed to have a protective effect against the increase in LDL-C and Lp(a) that are heavily involved in the development of cardiovascular diseases. © 2014 National Lipid Association. All rights reserved.
Authors & Co-Authors
Fekih, Ons
Tunisia, Monastir
Université de Monastir
Triki, Sonia
Tunisia, Monastir
Université de Monastir
Hellara, Ilhem
Tunisia, Monastir
Université de Monastir
Neffati, Fadoua
Tunisia, Monastir
Université de Monastir
Rejeb, Jihène
Tunisia, Sousse
Chu Sahloul
Ommezzine, Asma
Tunisia, Sousse
Chu Sahloul
Chouchane, Slaheddine
Tunisia, Monastir
Chu Fattouma-bourguiba
Gueddiche, Mohamed Néji
Tunisia, Monastir
Chu Fattouma-bourguiba
Bouslama, Ali
Tunisia, Sousse
Chu Sahloul
Najjar, M. F.
Tunisia, Monastir
Université de Monastir
Statistics
Citations: 12
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.jacl.2014.03.001
ISSN:
19332874
e-ISSN:
18764789
Research Areas
Genetics And Genomics
Maternal And Child Health
Noncommunicable Diseases
Study Design
Randomised Control Trial
Cross Sectional Study