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medicine

A novel extended-spectrum TEM-type β-lactamase, TEM-138, from Salmonella enterica serovar infantis

Antimicrobial Agents and Chemotherapy, Volume 50, No. 9, Year 2006

A novel natural TEM β-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N175I, and G238S. The blaTEM-138gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138. Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Statistics
Citations: 23
Authors: 7
Affiliations: 3
Identifiers
Doi: 10.1128/AAC.00388-06
ISSN: 00664804
Research Areas
Infectious Diseases

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