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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
PTEN mutations in uterine sarcomas
Gynecologic Oncology, Volume 85, No. 1, Year 2002
Notification
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Description
Objective. Uterine sarcomas comprise three main types: carcinosarcomas, leiomyosarcomas, and endometrial stromal sarcomas. Carcinosarcomas are highly aggressive neoplasms with a biphasic histology of carcinomatous and sarcomatous elements. It is now generally accepted that carcinosarcomas are biphasic tumors that have to be regarded as endometrial carcinomas where metaplasia occurs. Mutations of the PTEN tumor suppressor gene, located on 10q23, play a significant role in the pathogenesis of the endometrioid type of endometrial carcinoma. Loss of heterozygosity of chromosome i0q has been reported in uterine leiomyosarcoma. Since little is known about the molecular pathobiology, our goal was to investigate the potential role of the PTEN gene in the carcinogenesis of uterine sarcomas. Methods. We examined 21 carcinosarcomas, 21 leiomyosarcomas, and 5 endometrial stromal sarcomas using exon-by-exon polymerase chain reaction-single-strand conformation polymorphism analysis. Results. Overall 8.5% (4/47) of uterine sarcomas were found to harbor somatic PTEN mutations. Of these, ∼17% (3/18) were carcinosarcomas with endometrioid-type carcinoma components and ∼5% (1/21) were leiomyosarcomas. No mutations were detected in carcinosarcomas with nonendometrioid carcinoma components (0/3) and in endometrial stromal sarcomas (0/5). Conclusions. These data suggest that intragenic PTEN mutations are involved in the genesis of uterine carcinosarcomas with endometrioid-type carcinoma components but rarely contribute to the pathobiology of uterine leiomyosarcomas. © 2002 Elsevier Science (USA).
Authors & Co-Authors
Amant, Frédéric C.H.
Belgium, Leuven
Ku Leuven
South Africa, Pretoria
Steve Biko Academic Hospital
De la Rey, M.
South Africa, Pretoria
University of Pretoria
Dorfling, Cecilia M.
South Africa, Pretoria
University of Pretoria
Van der Walt, L.
South Africa, Pretoria
University of Pretoria
Dreyer, Greta
South Africa, Pretoria
Steve Biko Academic Hospital
Dreyer, Leonora
South Africa, Pretoria
University of Pretoria
VERGOTE, Ignace B.P.
Belgium, Leuven
Ku Leuven
Lindeque, Barend Gerhardus P.
South Africa, Pretoria
Steve Biko Academic Hospital
van Rensburg, Elizabeth J.
South Africa, Pretoria
University of Pretoria
Statistics
Citations: 49
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1006/gyno.2002.6601
ISSN:
00908258
Research Areas
Cancer
Genetics And Genomics