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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Heritability of the human infectious reservoir of malaria parasites
PLoS ONE, Volume 5, No. 6, Year 2010
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Description
Background: Studies on human genetic factors associated with malaria have hitherto concentrated on their role in susceptibility to and protection from disease. In contrast, virtually no attention has been paid to the role of human genetics in eliciting the production of parasite transmission stages, the gametocytes, and thus enhancing the spread of disease. Methods and Findings: We analysed four longitudinal family-based cohort studies from Senegal and Thailand followed for 2-8 years and evaluated the relative impact of the human genetic and non-genetic factors on gametocyte production in infections of Plasmodium falciparum or P. vivax. Prevalence and density of gametocyte carriage were evaluated in asymptomatic and symptomatic infections by examination of Giemsa-stained blood smears and/or RT-PCR (for falciparum in one site). A significant human genetic contribution was found to be associated with gametocyte prevalence in asymptomatic P. falciparum infections. By contrast, there was no heritability associated with the production of gametocytes for P. falciparum or P. vivax symptomatic infections. Sickle cell mutation, HbS, was associated with increased gametocyte prevalence but its contribution was small. Conclusions: The existence of a significant human genetic contribution to gametocyte prevalence in asymptomatic infections suggests that candidate gene and genome wide association approaches may be usefully applied to explore the underlying human genetics. Prospective epidemiological studies will provide an opportunity to generate novel and perhaps more epidemiologically pertinent gametocyte data with which similar analyses can be performed and the role of human genetics in parasite transmission ascertained. © Lawaly et al.
Available Materials
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https://efashare.b-cdn.net/share/pmc/articles/PMC2894056/bin/pone.0011358.s002.pdf
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https://efashare.b-cdn.net/share/pmc/articles/PMC2894056/bin/pone.0011358.s004.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC2894056/bin/pone.0011358.s005.doc
Authors & Co-Authors
Lawaly, Yaye Ramatoulaye
Senegal, Dakar
Institut Pasteur de Dakar
Sakuntabhai, Anavaj
France, Paris
Institut Pasteur, Paris
Marrama, Laurence
Senegal, Dakar
Institut Pasteur de Dakar
Konaté, Lassana
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Phimpraphi, Waraphon
France, Paris
Institut Pasteur, Paris
Thailand, Nakhon Pathom
Mahidol University
Sokhna, Cheikh Sadibou
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Tall, Adama
Senegal, Dakar
Institut Pasteur de Dakar
Sarr, Fatoumata Diène
Senegal, Dakar
Institut Pasteur de Dakar
Peerapittayamongkol, Chayanon
France, Paris
Institut Pasteur, Paris
Thailand, Bangkok
Faculty of Medicine Siriraj Hospital, Mahidol University
Louicharoen, Chalisa
France, Paris
Institut Pasteur, Paris
Thailand, Bangkok
Chulalongkorn University
Schneider, Bradley S.
France, Paris
Institut Pasteur, Paris
Levescot, Anaïs
France, Paris
Institut Pasteur, Paris
Talman, Arthur M.
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Casadémont, Isabelle
France, Paris
Institut Pasteur, Paris
Ménard, Didier
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Trape, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Rogier, Christophe
France, Marseille
Imtssa Institut de Médecine Tropicale du Service de Santé Des Armées
Kaewkunwal, Jaranit
Thailand, Nakhon Pathom
Mahidol University
Sura, Thanyachai
Thailand, Bangkok
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Nuchprayoon, Issarang
Thailand, Bangkok
Chulalongkorn University
Ariey, Frédéric
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Baril, Laurence
Senegal, Dakar
Institut Pasteur de Dakar
Singhasivanon, Pratap
Thailand, Nakhon Pathom
Mahidol University
Mercereau-Puijalon, Odile
France, Paris
Cnrs Centre National de la Recherche Scientifique
Paul, Richard P.C.
Senegal, Dakar
Institut Pasteur de Dakar
France, Paris
Institut Pasteur, Paris
Statistics
Citations: 43
Authors: 25
Affiliations: 11
Identifiers
Doi:
10.1371/journal.pone.0011358
e-ISSN:
19326203
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Locations
Senegal