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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cognitive outcomes and psychiatric symptoms of retinopathy-positive cerebral malaria: Cohort description and baseline results
American Journal of Tropical Medicine and Hygiene, Volume 97, No. 1, Year 2017
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Description
Cerebral malaria (CM) is a common cause of death and disability among children in sub-Saharan Africa. Many prior studies of neuropsychiatric morbidity have been limited by a cross-sectional design or a short duration of follow-up. Most have included subjects who may have presented with coma due to a disease process other than CM. No studies have assessed the relationship between magnetic resonance imaging (MRI) findings and long-term outcomes. The Cognitive Outcomes and Psychiatric symptoms of retinopathy-positive CM (COPS) cohort is the first large (N = 221) prospectively recruited cohort of stringently defined cases of CM and hospital-based, age-matched, non-CM controls in whom cognitive and psychiatric outcomes are assessed with standardized measures semi-annually for up to 5 years. We report baseline characteristics of the cohort and outcomes at 1 month. At enrollment,CMcases were more likely to come from families with fewer socioeconomic resources and to have health characteristics that increase risk for malaria. In children younger than 5 years, cases were delayed in motor, language, and social development by approximately 6 months, compared with controls. More significant delays occurred in those with MRI abnormalities at the 1-month follow-up visit. There were no differences between cases and controls in inhibitory self-control, nor in cognitive function in children ≥ 5 years of age. The latter finding may be related to the smaller sample size, case-control imbalance in socioeconomic status, or the use of cognitive and behavioral assessments that are less culturally appropriate to this population. Continued follow-up will help determine predictors of long-term outcomes. © 2017 by The American Society of Tropical Medicine and Hygiene.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC5508917/bin/tpmd170020.SD1.pdf
Authors & Co-Authors
Brim, Rachel
United States, East Lansing
Msu College of Osteopathic Medicine
Mboma, Sebastian M.
Malawi, Zomba
University of Malawi
Semrud-Clikeman, Margaret
United States, Minneapolis
University of Minnesota Twin Cities
Kampondeni, Sam D.
Malawi, Zomba
University of Malawi
Magen, Jed
United States, East Lansing
Msu College of Osteopathic Medicine
Taylor, Terrie Ellen
United States, East Lansing
Msu College of Osteopathic Medicine
Malawi, Zomba
University of Malawi
Langfitt, John
United States, Rochester
University of Rochester
Statistics
Citations: 21
Authors: 7
Affiliations: 4
Identifiers
Doi:
10.4269/ajtmh.17-0020
ISSN:
00029637
Research Areas
Disability
Health System And Policy
Infectious Diseases
Maternal And Child Health
Mental Health
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study