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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti
Tropical Medicine and International Health, Volume 12, No. 12, Year 2007
Notification
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Description
Objective: To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti. Method: In the Western Region of Ghana, 18 patients infected with W. bancrofti were recruited and treated with 200 mg doxycycline per day for 4 weeks. Seven untreated patients served as controls. Four months after doxycycline treatment, all patients received 150 μg/kg ivermectin. Patients were monitored for Wolbachia and microfilaria loads, antigenaemia and filarial dance sign (FDS). Results: Four months after doxycycline treatment, cases had a significantly lower Wolbachia load than controls; and 24 months after treatment, microfilaraemia, antigenaemia and frequency of FDS were significantly lower in cases than controls. Most importantly, 4 weeks of doxycycline killed 80% of macrofilariae, which is comparable with the results of a 6-week regimen. Circulating filarial antigenaemia and FDS were strongly correlated. Conclusion: A 4-week regimen of doxycycline seems sufficient to kill adult W. bancrofti and could be advantageous for the treatment of individual patients, e.g. in outpatient clinics. © 2007 Blackwell Publishing Ltd.
Authors & Co-Authors
Debrah, Yaw Alex
Unknown Affiliation
Mand, Sabine
Unknown Affiliation
Marfo-Debrekyei, Yeboah
Unknown Affiliation
Batsa, Linda
Unknown Affiliation
Pfarr, Kenneth M.
Unknown Affiliation
Büttner, Marcelle
Unknown Affiliation
Adjei, Ohene
Unknown Affiliation
Büttner, Dietrich W.
Unknown Affiliation
Hoerauf, Achim M.
Unknown Affiliation
Statistics
Citations: 105
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1111/j.1365-3156.2007.01949.x
ISSN:
13602276
e-ISSN:
13653156
Study Locations
Ghana