Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Systemic inflammatory response syndrome in patients with liver cirrhosis
Arab Journal of Gastroenterology, Volume 12, No. 4, Year 2011
Notification
URL copied to clipboard!
Description
Background and study aims: Patients with liver cirrhosis present an increased susceptibility to the systemic inflammatory response syndrome (SIRS), which is considered the cause of hospital admission in about 10% of patients and is present in about 40% of those admitted for ongoing complications. We tried to assess the prevalence of the SIRS with the possible effects on the course of the disease during hospital stay. Patients and methods: Two hundred and three patients with liver cirrhosis were examined and investigated with close monitoring during hospital stay. The main clinical endpoints were death and the development of portal hypertension-related complications. Results: Eighty-one patients met the criteria of SIRS (39.9%). We found significant correlations between SIRS and jaundice (p= 0.005), bacterial infection (p= 0.008), white blood cell count (p< 0.001), low haemoglobin concentration (p= 0.004), high serum creatinine levels (p< 0.001), high alanine aminotransferase levels (p< 0.001), serum bilirubin levels (p< 0.001), international normalised ratio (p< 0.001), serum albumin levels (p= 0.033), high Child-Pugh score (p< 0.001). During the follow-up period, 26 patients died (12.8%), 15 developed portal hypertension-related bleeding (7.3%), 30 developed hepatic encephalopathy (14.7%), and 9 developed hepatorenal syndrome type-1 (4.4%). SIRS showed significant correlations both to death (p< 0.001) and to portal hypertension-related complications (p< 0.001). Conclusion: The systemic inflammatory response syndrome occurs in patients with advanced cirrhosis and is associated with a bad prognosis. © 2011 Arab Journal of Gastroenterology.
Authors & Co-Authors
Abdel-Khalek, E. E.
Egypt, Mansoura
Faculty of Medicine
El-Fakhry, Ashraf A.
Egypt, Mansoura
Faculty of Medicine
Helaly, Mohamed Abdel Halem
Egypt, Mansoura
Faculty of Medicine
Hamed, Magdy
Egypt, Mansoura
Faculty of Medicine
Elbaz, Osama
Egypt, Mansoura
Faculty of Medicine
Statistics
Citations: 42
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1016/j.ajg.2011.11.006
ISSN:
16871979
e-ISSN:
20902387
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study