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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Unusual clinical presentation of cutaneous leishmaniasis in three diabetic patients
Annales de Dermatologie et de Venereologie, Volume 139, No. 8-9, Year 2012
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Description
Introduction: Cutaneous leishmaniasis (CL) is a parasitic infection characterized by significant clinical variability. Unusual and atypical clinical aspects of infection have been reported in immunodeficient patients or associated with particular parasite species. We report three cases of CL from foci of Leishmania major with a particular clinical presentation in diabetic patients. Observations: Patient 1: a 37-year-old man was admitted to the dermatology department for cutaneous vegetative ulcers spreading to the dorsal surface of the foot. History-taking revealed a stay in Er-Rachidia (East of Morocco, a known focus of CL L. major) six weeks earlier. Diabetes mellitus type I was discovered during hospitalization. The patient's 43-year-old sister (patient 2), diabetic for 6 years, consulted for a single leg ulcer appearing 3 months after the same trip to Er-Rachidia. Patient 3: a 61-year-old patient with a 7-year history of diabetes and under oral antidiabetics presented an extended vegetative lesion of the posterior surface of the leg 2 months after staying in Er-Rachidia. A diagnosis of CL was retained on the basis of epidemiology and history (living in an endemic areas of leishmaniasis), coupled in patients 1 and 3 with microbiological evidence involving identification of Leishmania bodies in skin smears or skin biopsies. All patients were treated with two intra-lesional injections per week of meglumine antimony (Glucantime®) for 6 weeks. The outcome was marked in all cases by healing of lesions and persistent pigmented scarring. Discussion: We described three particular clinical aspect of CL emerging from a known focus of L. major, where infection is classically associated with vegetative or ulcero-vegetative lesions. This unusual profile suggests the role of factors related to parasite species and/or diabetes found in our three patients. © 2012 Elsevier Masson SAS. Tous droits r éservés.
Authors & Co-Authors
Chiheb, Soumiya
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Oudrhiri, L.
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Zouhair, K.
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Soussi-Abdallaoui, Maha
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Riyad, Myriam
Morocco, Casablanca
Faculté de Médecine et de Pharmacie
Benchikhi, Hakima
Morocco, Casablanca
Centre Hospitalier Universitaire Ibn Rochd
Statistics
Citations: 9
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.annder.2012.05.013
ISSN:
01519638
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Locations
Morocco