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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Cyclosporin-associated nephropathy in patients with autoimmune diseases
Klinische Wochenschrift, Volume 66, No. 2, Year 1988
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Description
Renal biopsy specimens were evaluated from patients with different autoimmune diseases treated with cyclosporin (CyA). Ten biopsies were done before CyA, 10 biopsies after low-dose (<7.5 mg/kg/day, initial dose or mean daily dose within the first month, respectively), and 9 after high-dose (>7.5 mg/kg/day) treatment. Definite chronic CyA nephrotoxicity (cyclosporin-associated arteriolopathy and/or interstitial fibrosis striped form with tubular atrophy) was only present in the initial high-dose group. In this group a significant serum creatinine increase was noted and 8 of the 9 patients were hypertensive. No significant correlation was found between the severity of morphologic lesions and the mean daily dose during total treatment, cumulative dose, and duration of therapy. The morphologic changes in the low-dose group did not differ from the control biopsy specimens before CyA treatment. Based on these results, it can be concluded that major nephrotoxicity can be avoided by initial low CyA doses. © 1988 Springer-Verlag.
Authors & Co-Authors
Mihatsch, Michael Jörg
Switzerland, Basel
Universitätsspital Basel Institute of Pathology
Bach, Jean François
France, Paris
Hôpital Necker Enfants Malades
Coovadia, Hoosen Mahomed
South Africa, Durban
University of Kwazulu-natal
Førre,
Norway, Oslo
Oslo Sanitetsforening Rheumatism Hospital
Moutsopoulos, H. M.
Greece, Ioannina
University of Ioannina
Drosos, A. A.
Greece, Ioannina
University of Ioannina
Siamopoulos, K. C.
Greece, Ioannina
University of Ioannina
Noël, Laure Hélène
France, Paris
Hôpital Necker Enfants Malades
Ramsaroop, Reenadevi
South Africa, Durban
University of Kwazulu-natal
Hällgren, R.
Sweden, Uppsala
Akademiska Sjukhuset
Svenson, K.
Sweden, Uppsala
Akademiska Sjukhuset
Bohman, S. O.
Sweden, Stockholm
Karolinska Universitetssjukhuset
Statistics
Citations: 12
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1007/BF01713009
ISSN:
00232173
Research Areas
Noncommunicable Diseases