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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of the menstrual cycle on detection and typing of human papillomavirus in uterine cervical cells
American Journal of Obstetrics and Gynecology, Volume 162, No. 4, Year 1990
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Description
We observe fluctuations in human papillomavirus detection and variation in genotyping between sequential cervical cell specimens analyzed by filter in situ hybridization. Furthermore, specimen adequacy for analysis varies. To determine whether these phenomena are correlated with menstrual cycle stage at the time of sampling, we analyzed cervical cell specimens from women with cervical intraepithelial neoplasia. Specimens were categorized on the basis of a 28-day menstrual cycle and were analyzed by hybridization to combined probes for virus types 6 and 11 or types 16 and 18. Specimen adequacy was determined by hybridization to a human Alu I repetitive deoxyribonucleic acid probe. Analysis of data with χ2 revealed that fluctuations in virus detection and type variation are unrelated to menstrual cycle stage. Specimen adequacy is stage-dependent for women who take oral contraceptives. Whereas specimens can be collected at any time other than the first week of the menstrual cycle, accurate determination of infection status requires multiple assessments. © 1990.
Authors & Co-Authors
Guijón, Fernando B.
Canada, Winnipeg
University of Manitoba
Brunham, Robert C.
Canada, Winnipeg
University of Manitoba
Statistics
Citations: 15
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/0002-9378(90)91311-Y
ISSN:
00029378
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Sexual And Reproductive Health
Participants Gender
Female