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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Assessment of urinary concentrations of hepcidin provides novel insight into disturbances in iron homeostasis during malarial infection
Journal of Infectious Diseases, Volume 199, No. 2, Year 2009
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Description
Disturbances in iron homeostasis are frequently observed in individuals with malaria. To study the effect of malaria and its treatment on iron homeostasis and to provide a mechanistic explanation for observed alterations in iron distribution, we studied the course of the iron regulatory hormone hepcidin in anemic Tanzanian children with febrile Plasmodium falciparum malaria. Before initiation of antimalarial treatment, urinary concentrations of hepcidin were strongly elevated and were associated with iron maldistribution, as was suggested by the presence of hypoferremia and high serum concentrations of ferritin. Antimalarial treatment resulted in a rapid decrease in urinary concentrations of hepcidin and reversal of the hypoferremia. Exploration of regulatory pathways of hepcidin production by analysis of iron, erythropoietic, and inflammatory indices suggested that reduced erythropoietic activity and inflammation stimulated hepcidin production. We conclude that high concentrations of hepcidin explain the observed disturbances in host iron homeostasis associated with malaria and may contribute to malarial anemia and an impaired erythropoietic response to iron supplementation. © 2008 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
de Mast, Quirijn
Unknown Affiliation
Nadjm, Behzad
Unknown Affiliation
Reyburn, Hugh G.
Unknown Affiliation
Kemna, Erwin H.J.M.
Unknown Affiliation
Amos, Ben
Unknown Affiliation
Laarakkers, Coby M.M.
Unknown Affiliation
Silalye, Simphorosa
Unknown Affiliation
Verhoef, Hans
Unknown Affiliation
Sauerwein, Robert W.
Unknown Affiliation
Swinkels, Dorine W.
Unknown Affiliation
van der Ven, André J.A.M.
Unknown Affiliation
Statistics
Citations: 102
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1086/595790
ISSN:
00221899
Research Areas
Infectious Diseases
Maternal And Child Health