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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Timing of CMF chemotherapy in combination with tamoxifen in postmenopausal women with breast cancer: Role of endocrine responsiveness of the tumor
Annals of Oncology, Volume 16, No. 5, Year 2005
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Description
Background: Controversy persists about whether chemotherapy benefits all breast cancer patients. Patients and methods: In the International Breast Cancer Study Group (IBCSG) trial VII, 1212 postmenopausal patients with node-positive disease were randomized to receive tamoxifen for 5 years or tamoxifen plus three concurrent courses of cyclophosphamide, methotrexate and 5-fluorouracil ('classical' CMF) chemotherapy, either early, delayed or both. In IBCSG trial IX, 1669 postmenopausal patients with node-negative disease were randomized to receive either tamoxifen alone or three courses of adjuvant classical CMF prior to tamoxifen. Results were assessed according to estrogen receptor (ER) content of the primary tumor. Results: For patients with node-positive, ER-positive disease, adding CMF either early, delayed or both reduced the risk of relapse by 21% (P = 0.06), 26% (P = 0.02) and 25% (P = 0.02), respectively, compared with tamoxifen alone. There was no difference in disease-free survival when CMF was given prior to tamoxifen in patients with node-negative, ER-positive tumors. Conclusions: CMF given concurrently (early, delayed or both) with tamoxifen was more effective than tamoxifen alone for patients with node-positive, endocrine-responsive breast cancer, supporting late administration of chemotherapy even after commencement of tamoxifen. In contrast, sequential CMF and tamoxifen for patients with node-negative, endocrine-responsive disease was ineffective. © 2005 European Society for Medical Oncology.
Authors & Co-Authors
Colleoni, Marco Angelo
Unknown Affiliation
Li, Sigui
Unknown Affiliation
Gelber, Richard D.
Unknown Affiliation
Coates, Alan S.
Unknown Affiliation
Castiglione-Gertsch, Monica
Unknown Affiliation
Price, Karen N.
Unknown Affiliation
Lindtner, Jurij
Unknown Affiliation
Rudenstam, Carl Magnus
Unknown Affiliation
Crivellari, Diana
Unknown Affiliation
Collins, John Paxton
Unknown Affiliation
Pagani, O.
Unknown Affiliation
Simoncini, Edda Lucia
Unknown Affiliation
Thürlimann, Beat J.K.
Unknown Affiliation
Murray, Elizabeth M.
Unknown Affiliation
Forbes, John Frederick
Unknown Affiliation
Eržen, Darja
Unknown Affiliation
Holmberg, Stig B.
Unknown Affiliation
Veronesi, Andreas
Unknown Affiliation
Goldhirsch, Aaron
Unknown Affiliation
Senn, Hansjörg
Unknown Affiliation
Cortés-Funés, Hernán
Unknown Affiliation
Nasi, M. L.
Unknown Affiliation
Hiltbrunner, Anita
Unknown Affiliation
Egli, G.
Unknown Affiliation
Jenatsch, C.
Unknown Affiliation
Rabaglio, Manuela
Unknown Affiliation
Bonetti, M.
Unknown Affiliation
Zahrieh, David M.
Unknown Affiliation
Zelen, M.
Unknown Affiliation
Gelber, Shari E.
Unknown Affiliation
O'Neill, Anne Marie
Unknown Affiliation
Keshaviah, A.
Unknown Affiliation
Regan, Meredith M.
Unknown Affiliation
Cole, Bernard F.
Unknown Affiliation
Blacher, Lynette
Unknown Affiliation
Isley, Mary R.
Unknown Affiliation
Hinkle, Rita
Unknown Affiliation
Lippert, Sandra
Unknown Affiliation
Celano, J.
Unknown Affiliation
Scott, Karolyn
Unknown Affiliation
Scolese, T.
Unknown Affiliation
Gusterson, Barry A.
Unknown Affiliation
Viale, Giuseppe L.
Unknown Affiliation
Mallon, Elizabeth A.
Unknown Affiliation
Monfardini, Silvio
Unknown Affiliation
Galligioni, Enzo
Unknown Affiliation
Buonadonna, Angela
Unknown Affiliation
Massarut, Samuele
Unknown Affiliation
Rossi, Carlo Remigio
Unknown Affiliation
Candiani, Ezio
Unknown Affiliation
Carbone, Antonino
Unknown Affiliation
Volpe, Rachele
Unknown Affiliation
Roncadin, Mario
Unknown Affiliation
Arcicasa, Mauro
Unknown Affiliation
Santini, G. F.
Unknown Affiliation
Villalta, F.
Unknown Affiliation
Coran, Francesco
Unknown Affiliation
Morassut, Sandro
Unknown Affiliation
Magri, Marisa Donatella
Unknown Affiliation
Marini, Giovanni
Unknown Affiliation
Marpicati, Patrizia
Unknown Affiliation
Bami, A.
Unknown Affiliation
Grigolato, Piergiovanni
Unknown Affiliation
Morassi, Laura L.
Unknown Affiliation
Sartori, U.
Unknown Affiliation
DiLorenzo, D.
Unknown Affiliation
Albertini, A.
Unknown Affiliation
Matinone, G.
Unknown Affiliation
Zorzi, M.
Unknown Affiliation
Braga, Marco
Unknown Affiliation
Lucini, Laura
Unknown Affiliation
Foladore, Silvia
Unknown Affiliation
Foghin, Liliana
Unknown Affiliation
Pamich, G.
Unknown Affiliation
Bianchi, Claudio
Unknown Affiliation
Marino, B.
Unknown Affiliation
Murgia, Alma
Unknown Affiliation
Milan, Vittorino
Unknown Affiliation
Dent, David M.
Unknown Affiliation
Gudgeon, Anne
Unknown Affiliation
Werner, I. Dudley
Unknown Affiliation
Steynor, P.
Unknown Affiliation
Hacking, Anne
Unknown Affiliation
Terblanche, John T.
Unknown Affiliation
Tiltman, Andrew John
Unknown Affiliation
Dowdle, Eugene B.D.
Unknown Affiliation
Sealy, Rossall G.H.
Unknown Affiliation
Palmer, P.
Unknown Affiliation
Helman, Percy
Unknown Affiliation
McEvoy, Elene
Unknown Affiliation
Toop, J.
Unknown Affiliation
Vorobiof, Daniel Alberto
Unknown Affiliation
Chasen, Martin Robert
Unknown Affiliation
Fotheringham, G.
Unknown Affiliation
de Muelenaere, G.
Unknown Affiliation
Skudowitz, Ben
Unknown Affiliation
Mohammed, C.
Unknown Affiliation
Rosengarten, A.
Unknown Affiliation
Statistics
Citations: 98
Authors: 98
Affiliations: 18
Identifiers
Doi:
10.1093/annonc/mdi163
ISSN:
09237534
Research Areas
Cancer
Participants Gender
Female