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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Burden of respiratory syncytial virus in hospitalized infants and young children in Amman, Jordan
Scandinavian Journal of Infectious Diseases, Volume 42, No. 5, Year 2010
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Description
Acute respiratory infections (ARI) play a major role in hospitalizations in the Middle East, but the specific viral causes are unknown. We conducted prospective viral surveillance in children <5 y of age admitted with ARI and/or fever at 2 dissimilar hospitals in Amman, Jordan during peak respiratory syncytial virus (RSV) season. We collected prospective clinical and demographic data and obtained nose/throat swabs for testing for RSV by real-time polymerase chain reaction (RT-PCR). We obtained clinical and laboratory data for 728/743 (98%) subjects enrolled. The children's median age was 4.3 months, 58.4% were males, 87% were breastfed, 4% attended day care, 67% were exposed to smokers, 7% were admitted to the intensive care unit, and 0.7% died (n = 5). Out of 728 subjects, 467 (64%) tested positive by RT-PCR for RSV. Comparing RSV-positive with RSV-negative subjects, the RSV-positive subjects had lower median age (3.6 vs 6.4 months, p < 0.001) and fewer males (55% vs 64%, p = 0.02). RSV-positive children had higher rates of oxygen use (72% vs 42%, p < 0.001), a longer hospital stay (5 vs 4 days, p = 0.001), and higher hospital charges (US$538 vs US$431, p < 0.001) than RSV-negative children. In young hospitalized Jordanian infants, the medical and financial burden of RSV was found to be high. Effective preventive measures, such as an RSV vaccine, would have a significant beneficial impact. © Informa UK Ltd.
Authors & Co-Authors
Khuri-Bulos, Najwa A.
Jordan, Amman
The University of Jordan
Williams, John V.
United States, Nashville
Vanderbilt University School of Medicine
Shehabi, Asem Ata
Jordan, Amman
The University of Jordan
Faouri, Samir
Jordan, Amman
Al-bashir Hospital
Jundi, Ehsan Al
Saudi Arabia, Al-khobar
Saad Specialist Hospital
Abushariah, Omar
Jordan, Amman
Al-bashir Hospital
Chen, Qingxia
United States, Nashville
Vanderbilt University School of Medicine
Ali, Asad S.
United States, Nashville
Vanderbilt University School of Medicine
Pakistan, Karachi
The Aga Khan University
Vermund, Sten Havlor
United States, Nashville
Vanderbilt University School of Medicine
Halasa, Natasha B.
United States, Nashville
Vanderbilt University School of Medicine
Statistics
Citations: 31
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.3109/00365540903496544
ISSN:
00365548
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study