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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis
Arthritis and Rheumatology, Volume 74, No. 3, Year 2022
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Description
Objective: To develop and validate classification criteria for microscopic polyangiitis (MPA). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate items using consensus methodology, 2) prospective collection of candidate items present at the time of diagnosis, 3) data-driven reduction of the number of candidate items, 4) expert panel review of cases to define the reference diagnosis, and 5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators. Results: The development set for MPA consisted of 149 cases of MPA and 408 comparators. The validation set consisted of an additional 142 cases of MPA and 414 comparators. From 91 candidate items, regression analysis identified 10 items for MPA, 6 of which were retained. The final criteria and their weights were as follows: perinuclear antineutrophil cytoplasmic antibody (ANCA) or anti–myeloperoxidase-ANCA positivity (+6), pauci-immune glomerulonephritis (+3), lung fibrosis or interstitial lung disease (+3), sino-nasal symptoms or signs (−3), cytoplasmic ANCA or anti–proteinase 3 ANCA positivity (−1), and eosinophil count ≥1 × 109/liter (−4). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having MPA with a cumulative score of ≥5 points. When these criteria were tested in the validation data set, the sensitivity was 91% (95% confidence interval [95% CI] 85–95%) and the specificity was 94% (95% CI 92–96%). Conclusion: The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for MPA are now validated for use in clinical research. © 2022 American College of Rheumatology.
Authors & Co-Authors
Robson, Joanna C.
United Kingdom, Bristol
University Hospitals Bristol and Weston Nhs Foundation Trust
Khalid, Sara
United Kingdom, Oxford
University of Oxford
Judge, Andrew D.
United Kingdom, Bristol
University of Bristol
Hutchings, Andrew
United Kingdom, London
London School of Hygiene & Tropical Medicine
Hill, Catherine Louise
Unknown Affiliation
Kronbichler, Andreas
Unknown Affiliation
Pagnoux, Christian
Unknown Affiliation
Khalidi, Nader A.
Unknown Affiliation
Tesarˇ, Vladimír
Unknown Affiliation
Hammam, Nevin
Unknown Affiliation
Shahin, Amira A.
Unknown Affiliation
Putaala, Jukka
Unknown Affiliation
Henes, Jörg Christoph
Unknown Affiliation
Schmidt, Wolfgang A.
Unknown Affiliation
Szekanecz, Zoltán A.
Unknown Affiliation
Danda, Debashish
Unknown Affiliation
Sharma, Aman K.
Unknown Affiliation
Salvarani, Carlo
Unknown Affiliation
Harigai, Masayoshi
Unknown Affiliation
Takeuchi, Tsutomu
Unknown Affiliation
Tak, Paul Peter
Unknown Affiliation
Grainger, Rebecca
Unknown Affiliation
Stamp, Lisa K.
Unknown Affiliation
Diamantopoulos, Andreas P.
Unknown Affiliation
Sznajd, Jan
Unknown Affiliation
Azevedo, E. Irene
Unknown Affiliation
Rodrigues, Miguel
Unknown Affiliation
Song, Yeoungwook
Unknown Affiliation
Moiseev, Sergey V.
Unknown Affiliation
Hocˇevar, Alojzija
Unknown Affiliation
Cid, Maria C.
Unknown Affiliation
Daikeler, Thomas D.
Unknown Affiliation
Direskeneli, Haner
Unknown Affiliation
Hatemi, Gulen
Unknown Affiliation
Dasgupta, Bhaskar
Unknown Affiliation
Gendi, Nagui S.T.
Unknown Affiliation
Jayne, David R.W.
Unknown Affiliation
Lanyon, Peter Charles
Unknown Affiliation
McInnes, Iain B.
Unknown Affiliation
McLaren, John Stuart
Unknown Affiliation
Morgan, Ann W.
Unknown Affiliation
Mukhtyar, Chetan B.
Unknown Affiliation
Watts, Richard A.
Unknown Affiliation
Calabrese, Leonard H.
Unknown Affiliation
Matteson, Eric L.
Unknown Affiliation
Statistics
Citations: 40
Authors: 45
Affiliations: 9
Identifiers
Doi:
10.1002/art.41983
ISSN:
23265191
Research Areas
Health System And Policy
Study Design
Cohort Study
Study Approach
Quantitative