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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Meta-Analysis of Intrauterine Device Use and Risk of Endometrial Cancer
Annals of Epidemiology, Volume 18, No. 6, Year 2008
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Description
Purpose: We sought to study the association between intrauterine device (IUD) use and endometrial cancer. Methods: A comprehensive search of literature published through April 2007 was conducted, studies reviewed, and data abstracted. Data from ten studies were pooled and analyzed using both fixed- and random-effects models to examine the association of ever use of an IUD and endometrial cancer. Results: Based on the random effects model, a protective crude association between IUD use and endometrial cancer was observed (odds ratio [OR] = 0.39; 95% confidence interval [CI] = 0.29-0.51; heterogeneity p < 0.001) with a pooled adjusted risk of OR = 0.54 (95% CI, 0.47-0.63; heterogeneity p = 0.40). A decreased risk of endometrial cancer also was seen for increased years of IUD use (OR for 5 years of use 0.88; 95% CI = 0.84-0.92; n = 5; heterogeneity p = 0.14), increased years since last IUD use (OR for 5 years of use 0.91; 95% CI, 0.86-0.95; n = 4; heterogeneity p = 0.02), and increased years since first IUD use (OR for 5 years of use 0.89; 95% CI, 0.83-0.95; n = 4; heterogeneity p = 0.04). Conclusions: Our results suggest that nonhormonal IUD use may be associated with a decreased risk for endometrial cancer; however, the exact mechanism for this association is unclear. Future investigations should address the difference in the proposed association by specific type of IUDs. © 2008 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Beining, Robin M.
Guinea, Health
College of Public
Dennis, Leslie K.
Guinea, Health
College of Public
Smith, Elaine M.
Guinea, Health
College of Public
United States, Iowa City
University of Iowa
Dokras, Anuja
United States, Iowa City
University of Iowa
Statistics
Citations: 87
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/j.annepidem.2007.11.011
ISSN:
10472797
Research Areas
Cancer
Genetics And Genomics
Study Design
Case-Control Study
Study Approach
Systematic review