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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
PLoS ONE, Volume 8, No. 5, Article e63181, Year 2013
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Description
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p<0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p<0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p<0.01) and younger age (OR 0.62; CI 0.49-0.90; p<0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p<0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences. © 2013 Chambers et al.
Authors & Co-Authors
Chambers, S. T.
New Zealand, Christchurch
Christchurch Hospital new Zealand
New Zealand, Dunedin
University of Otago
Murdoch, David Roger
New Zealand, Christchurch
Christchurch Hospital new Zealand
New Zealand, Dunedin
University of Otago
Morris, Arthur James
New Zealand, Auckland
Auckland City Hospital
Holland, David James
New Zealand, Auckland
Middlemore Hospital, Auckland
Pappas, Paul A.
United States, Durham
Duke University Medical Center
Almela, Manuel Vidal
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Fernández-Hidalgo, Núria
Spain, Barcelona
Hospital Universitari Vall D'hebron
Almirante, Benito
Spain, Barcelona
Hospital Universitari Vall D'hebron
Bouza, E. Santiago
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Forno, Davide
Italy, Turin
Ospedale Maria Vittoria
Italy, Vittoria
Maria Vittoria Hospital
del Río, Ana I.Quintero
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Hannan, Margaret M.
Ireland, Dublin
Mater Misericordiae University Hospital
Ireland
Mater Hospitals
Harkness, John L.
Australia, Sydney
St Vincent's Pathology
Kanafani, Zeina A.
Lebanon, Beirut
American University of Beirut
Lalani, Tahaniyat N.
United States, Rockville
National Cancer Institute Nci
United States, Durham
Duke University Medical Center
Lang, Selwyn D.R.
New Zealand, Auckland
Middlemore Hospital, Auckland
Raymond, Nigel J.
New Zealand, Wellington
Wellington Hospital, new Zealand
United Kingdom, Wellington
Wellington Hospital
Read, Kerry M.
New Zealand, Auckland
North Shore Hospital
Vinogradova, Tatiana L.
Russian Federation, Moscow
Pirogov Russian National Research Medical University Rnrmu
Woods, Christopher W.
United States
Va Medical Center
United States, Durham
Duke University Medical Center
Wray, Dannah W.
United States, Charleston
Medical University of South Carolina
Corey, Gordon Ralph
United States, Durham
Duke University Medical Center
Chu, Vivian H.
United States, Durham
Duke University Medical Center
Clara, Liliana O.
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Sánchez, Marisa Carmen
Argentina, Buenos Aires
Instituto Universitario Del Hospital Italiano de Buenos Aires
Nacinovich, Francisco M.
Argentina
Instituto Cardiovascular
Oses, Pablo Fernández
Argentina
Instituto Cardiovascular
Ronderos, Ricardo Ernesto
Argentina
Instituto Cardiovascular
Súcari, Adriana
Argentina
Instituto Cardiovascular
Thierer, Jorge Mario
Argentina
Instituto Cardiovascular
Casabe´, José Horacio
Argentina
Hospital Universitario de la Fundacio`n Favaloro
Cortés, Claudia Mariana
Argentina
Hospital Universitario de la Fundacio`n Favaloro
Altclas, Javier David
Argentina, Buenos Aires
Sanatorio de la Trinidad
Silvia Kogan, Sanatorio
Argentina, Buenos Aires
Sanatorio de la Trinidad
Spelman, Denis W.
Australia, Melbourne
The Alfred
Athan, E.
Australia, Geelong
Barwon Health
Harris, Owen C.
Australia, Geelong
Barwon Health
Kennedy, Karina J.
Australia, Canberra
Canberra Hospital
Tan, Ren
Australia, Canberra
Canberra Hospital
Gordon, David Llewellyn
Australia, Adelaide
Flinders Medical Centre
Papanicolas, Lito Electra
Australia, Adelaide
Flinders Medical Centre
Eisen, Damon P.
Australia, Melbourne
Royal Melbourne Hospital
Grigg, Leeanne Elizabeth
Australia, Melbourne
Royal Melbourne Hospital
Street, Alan C.
Australia, Melbourne
Royal Melbourne Hospital
Korman, Tony M.
Unknown Affiliation
Kotsanas, Despina
Unknown Affiliation
Dever, Robyn
Australia, Sydney
St George Hospital
Jones, Philip D.
Australia, Sydney
St George Hospital
Australia, Sydney
St Vincent's Pathology
Australia, Sutherland
Sutherland Institute
Australia, Sydney
Unsw Sydney
Konecny, Pam
Australia, Sydney
St George Hospital
Lawrence, Richard H.
Australia, Sydney
St George Hospital
Rees, David M.
Australia, Sydney
St George Hospital
Ryan, Suzanne
Australia, Sydney
St George Hospital
Australia, Sydney
St Vincent's Pathology
Australia, Sutherland
Sutherland Institute
Australia, Sydney
Unsw Sydney
Feneley, Michael P.
Australia, Sydney
St Vincent's Pathology
Post, Jeffrey J.
Australia, Sydney
Unsw Sydney
Reinbott, Porl
Australia, Sydney
Unsw Sydney
Gattringer, Rainer
Austria, Vienna
Allgemeines Krankenhaus Wien
Wiesbauer, Franz
Austria, Vienna
Allgemeines Krankenhaus Wien
Andrade, Adriana Ribas
Brazil
Ana Neri Hospital
de Brito, Ana Cla´udia Passos
Brazil
Ana Neri Hospital
Guimara~es, Armenio Costa
Brazil
Ana Neri Hospital
Grínberg, Max
Brazil, Sao Paulo
Universidade de São Paulo
Mansur, José Alfredo
Brazil, Sao Paulo
Universidade de São Paulo
Siciliano, Rinaldo Focaccia
Brazil, Sao Paulo
Universidade de São Paulo
Strabelli, Tania Mara Varejao
Brazil, Sao Paulo
Universidade de São Paulo
Vieira, Marcelo Luiz Campos
Brazil, Sao Paulo
Universidade de São Paulo
de Medeiros Tranchesi, Regina Aparecida
Brazil, Sao Paulo
Hospital 9 de Julho
Paiva, Marcelo Goulart
Brazil, Sao Paulo
Hospital 9 de Julho
Fortes, Claudio Querido
Brazil, Rio de Janeiro
Universidade Federal do Rio de Janeiro
de Oliveira Ramos, Auristela Isabel
Brazil, Sao Paulo
Instituto Dante Pazzanese de Cardiologia
Ferraiuoli, Giovanna Ianini D.Almeida
Mexico
Instituto Nacional de Cardiologi
Golebiovski, Wilma Felix
Mexico
Instituto Nacional de Cardiologi
Lamas, C. C.
Mexico
Instituto Nacional de Cardiologi
Santos, Marisa Silva
Mexico
Instituto Nacional de Cardiologi
Weksler, Clara
Mexico
Instituto Nacional de Cardiologi
Karlowsky, James A.
Canada, Winnipeg
University of Manitoba
Keynan, Y.
Canada, Winnipeg
University of Manitoba
Morris, Andrew Mark
Canada, Winnipeg
University of Manitoba
Rubinstein, Ethan
Canada, Winnipeg
University of Manitoba
Israel, Tel Aviv-yafo
Tel Aviv University
Jones, Sandra Braun
Chile, Santiago
Pontificia Universidad Católica de Chile
García, Patricia Muñoz
Chile, Santiago
Pontificia Universidad Católica de Chile
Cereceda, Mauricio
Chile, Santiago
Universidad de Chile
Fica C, Alberto E.
Chile, Santiago
Universidad de Chile
Mella, Rodrigo Montagna
Chile, Santiago
Universidad de Chile
Barŝić, Bruno U.
Croatia
University Hospital for Infectious Diseases
Bukovski, Suzana
Croatia
University Hospital for Infectious Diseases
Krajinović, Vladimir
Croatia
University Hospital for Infectious Diseases
Pangerčić, Ana
Croatia
University Hospital for Infectious Diseases
Rudež, Igor
Croatia
University Hospital for Infectious Diseases
Vincelj, Josip
Croatia
University Hospital for Infectious Diseases
Freiberger, Tomas
Czech Republic, Brno
Centre for Cardiovascular Surgery and Transplantation
Pol, Jiří
Czech Republic, Brno
Centre for Cardiovascular Surgery and Transplantation
Žaloudíková, Barbora
Czech Republic, Brno
Centre for Cardiovascular Surgery and Transplantation
Ashour, Zainab
Egypt, Cairo
Faculty of Medicine
Kholy, Amani El
Egypt, Cairo
Faculty of Medicine
Mishaal, Marwa
Egypt, Cairo
Faculty of Medicine
Rizk, Hussien Hassan
Egypt, Cairo
Faculty of Medicine
Aissa, Neijla
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Alauzet, Corentine
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Alla, François F.
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Campagnac, Catherine
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Doco-Lecompte, Thanh
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Selton-Suty, Christine
France, Vandoeouvre-les-nancy
Hôpital Brabois Adultes
Casalta, Jean Paul
France, Marseille
Aix Marseille Université
Fournier, Pierre Édouard
France, Marseille
Aix Marseille Université
Habib, Gilbert B.
France, Marseille
Aix Marseille Université
Raoult, Didier A.
France, Marseille
Aix Marseille Université
Thuny, Franck Roland
France, Marseille
Aix Marseille Université
Delahaye, Franc¸ois
France, Lyon
Hopital Louis Pradel
Delahaye, Armelle
France, Lyon
Hopital Louis Pradel
Vandenesch, François
France, Lyon
Hopital Louis Pradel
Donal, Erwan
France, Rennes
Pontchaillou University
Donnio, Pierre Yves
France, Rennes
Pontchaillou University
Michelet, Christian
France, Rennes
Pontchaillou University
Tattevin, Pierre
France, Rennes
Pontchaillou University
Ruşinaru, Dan M.D.
France, Amiens
Chu Amiens Picardie
Tribouilloy, Christophe M.
France, Amiens
Chu Amiens Picardie
Bernard, Yvette F.
France, Besancon
University Medical Center of Besançon
Chirouze, Catherine
France, Besancon
University Medical Center of Besançon
Hoën, Bruno
France, Besancon
University Medical Center of Besançon
Leroy, Joël E.
France, Besancon
University Medical Center of Besançon
Plèsiat, Patrick
France, Besancon
University Medical Center of Besançon
Giannitsioti, Efthymia
Greece, Athens
Attikon University Hospital
Paniara, Olga I.
Greece, Athens
Evagelismos Hospital
Skoutelis, Athanasios Th
Greece, Athens
Evagelismos Hospital
Francis, Johnson
India, Kozhikode
Calicut Medical College
Thomas, Vinod
India, Kozhikode
Calicut Medical College
Venugopal, Krishnan
India, Kozhikode
Calicut Medical College
Hurley, John P.
Ireland
Mater Hospitals
Korem, Maya
Israel, Jerusalem
Hebrew University of Jerusalem
Strahilevitz, Jacob
Israel, Jerusalem
Hebrew University of Jerusalem
Israel, Tel Aviv-yafo
Tel Aviv University
Tripodi, Marie Franc¸oise
Italy, Salerno
Università Degli Studi Di Salerno
Cuccurullo, Susanna
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Dialetto, Giovanni
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Durante-Mangoni, Emanuele
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Cecchi, Enrico
Italy, Vittoria
Maria Vittoria Hospital
De Rosa, Francesco Giuseppe
Italy, Vittoria
Maria Vittoria Hospital
Imazio, Massimo M.
Italy, Vittoria
Maria Vittoria Hospital
Tebini, Alessandro
Italy, Varese
Azienda Ospedaliera Ospedale Di Circolo e Fondazione Macchi Di Varese
Grossi, Paolo Antonio
Italy, Varese
Azienda Ospedaliera Ospedale Di Circolo e Fondazione Macchi Di Varese
Raglio, Annibale
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Ravasio, Veronica
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Rizzi, Marco
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Suter, Fredy
Italy, Bergamo
Ospedali Riuniti Di Bergamo
Carosi, Giaampiero
Italy, Brescia
Spedali Civili Di Brescia
Baban, Tania A.
Lebanon, Beirut
American University of Beirut
Kanj, Souha S.
Lebanon, Beirut
American University of Beirut
Yasmin, Mohamad
Lebanon, Beirut
American University of Beirut
Tamin, Syahidah Syed
Malaysia
National Heart Institute
van der Meer, Jan T.M.
Netherlands, Amsterdam
Universiteit Van Amsterdam
Drãgulescu, Ştefan Iosif
Romania, Bucharest
Victor Babes National Institute
Edathodu, Jameela
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Halim, Magid Abdel
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Tan, Ru San
Singapore, Singapore City
National Heart Centre Singapore
Lejko-Zupanc, Tatjana
Slovenia, Ljubljana
Medical Center Ljublijana
Logar, Mateja
Slovenia, Ljubljana
Medical Center Ljublijana
Mueller-Premru, Manica
Slovenia, Ljubljana
Medical Center Ljublijana
Commerford, Patrick Joseph
South Africa, Observatory
Groote Schuur Hospital
Commerford, Anita
South Africa, Observatory
Groote Schuur Hospital
Deetlefs, Eduan
South Africa, Observatory
Groote Schuur Hospital
Hansa, Cass
South Africa, Observatory
Groote Schuur Hospital
Ntsekhe, Mpiko
South Africa, Observatory
Groote Schuur Hospital
Armero, Yolanda
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Azqueta, Manel
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Cervera, Carlos García
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Falces, Carlos
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
García-De-La-Mària, Cristina
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Gatell, José Mariá A.
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Marco, Francesc
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Mestres, Carlos Alberto
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Miró, José María
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Moreno, Asunciõn Pizarro
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Ninot, Salvador
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Parè, Carles
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Pericàs, Joan Manuel
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Ramírez, José Luís De Francisco
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Sitges, Marta
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Anguera, Ignasi
Spain, Sabadell
Hospital de Sabadell
Rodri´guez-Cre´ixems, Marta R.
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Tornos, Pilar
Spain, Barcelona
Hospital Universitari Vall D'hebron
de Alarcón, Ari´stides
Spain, Sevilla
Hospital Universitario Virgen Del Rocío
Olaison, Lars
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Snygg-Martin, Ulrika
Sweden, Gothenburg
Sahlgrenska Universitetssjukhuset
Pachirat, O.
Thailand, Khon Kaen
Khon Kaen University
Casey, Anna L.
United Kingdom, Elizabeth
Queen Elizabeth Hospital
Elliott, Thomas S.J.
United Kingdom, Elizabeth
Queen Elizabeth Hospital
Lambert, Peter A.
United Kingdom, Elizabeth
Queen Elizabeth Hospital
Watkin, Richard W.
United Kingdom, Elizabeth
Queen Elizabeth Hospital
Klein, John L.
United Kingdom, London
St Thomas' Hospital
Kauffman, Carol A.
United States, Ann Arbor
Va Ann Arbor Healthcare System
Bedimo, Roger J.
United States
Va Medical Center
Drew, Laura A.
United States, Durham
Duke University Medical Center
Fowler, Vance G.
United States, Durham
Duke University Medical Center
Holland, Thomas L.
United States, Durham
Duke University Medical Center
Mudrick, Daniel W.
United States, Durham
Duke University Medical Center
Samad, Zainab
United States, Durham
Duke University Medical Center
Sexton, Daniel J.
United States, Durham
Duke University Medical Center
Stryjewski, Martín E.
United States, Durham
Duke University Medical Center
Wang, Andrew
United States, Durham
Duke University Medical Center
Lerakis, Stamatios
United States, Atlanta
Emory University
Cantey, Robert
United States, Charleston
Medical University of South Carolina
Steed, Lisa L.
United States, Charleston
Medical University of South Carolina
Dickerman, Stuart A.
United States, New York
Nyu Langone Health
DiPersio, Joseph R.
United States, Akron
Summa Health System
Baddley, John W.
United States, Birmingham
The University of Alabama at Birmingham
Patel, Mukesh
United States, Birmingham
The University of Alabama at Birmingham
Peterson, Gail E.
United States, Dallas
Ut Southwestern Medical Center
Stancoven, Amy Butler
United States, Dallas
Ut Southwestern Medical Center
Afonso, Luis C.
United States, Detroit
Wayne State University
Cabell, Christopher H.
United States, Durham
Iqvia Inc.
Fowler, Vance G.
Unknown Affiliation
Park, Lawrence P.
Unknown Affiliation
Bayer, Arnold S.
Unknown Affiliation
Karchmer, Adolf W.
Unknown Affiliation
Durack, David T.
Unknown Affiliation
Eykyn, Susannah J.
Unknown Affiliation
Moreillon, Philippe
Unknown Affiliation
Statistics
Citations: 195
Authors: 216
Affiliations: 88
Identifiers
Doi:
10.1371/journal.pone.0063181
ISSN:
19326203
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative