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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mitochondrial DNA genetic diversity among four ethnic groups in Sierra Leone
American Journal of Physical Anthropology, Volume 128, No. 1, Year 2005
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Description
Although there are numerous ethnic groups in Sierra Leone, the Mende and Temne together account for approximately 60% of the total population. To see if genetic differences could be observed among ethnic groups in Sierra Leone, the nucleotide sequence of the hypervariable 1 (HV1) region of mitochondrial DNA (mtDNA) was determined from samples of the two major ethnic groups, the Mende (n = 59) and Temne (n = 121), and of two minor ethnic groups, the Loko (n = 29) and Limba (n = 67). Among these 276 HV1 sequences, 164 individual haplotypes were observed. An analysis of molecular variance indicated that the distribution of these haplotypes within the Limba sample was significantly different from that of the other ethnic groups. No significant genetic variation was seen between the Mende, Temne, and Loko. These results indicate that distinguishing genetic differences can be observed among ethnic groups residing in historically close proximity to one another. Furthermore, we observed some mitochondrial DNA haplotypes that are common among the Sierra Leone ethnic groups but that have not been observed in other published studies of West African ethnic groups. Therefore, we may have evidence for mtDNA lineages that are unique to this region of West Africa. © 2005 Wiley-Liss, Inc.
Authors & Co-Authors
Jackson, Bruce A.
Unknown Affiliation
Wilson, Jamie Lee
Unknown Affiliation
Kirbah, Salwa
Unknown Affiliation
Sidney, Sheree S.
Unknown Affiliation
Rosenberger, Joshua
Unknown Affiliation
Bassie, Larry
Unknown Affiliation
Alie, Joe A.D.
Unknown Affiliation
McLean, David C.
Unknown Affiliation
Garvey, William Timothy
Unknown Affiliation
Ely, Bert
Unknown Affiliation
Statistics
Citations: 50
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1002/ajpa.20040
ISSN:
00029483
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Multi-countries
Sierra Leone