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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemical engineering
Aortic valve leaflet mechanical properties facilitate diastolic valve function
Computer Methods in Biomechanics and Biomedical Engineering, Volume 13, No. 2, Year 2010
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Description
This work was concerned with the numerical simulation of the behaviour of aortic valves whose material can be modelled as non-linear elastic anisotropic. Linear elastic models for the valve leaflets with parameters used in previous studies were compared with hyperelastic models, incorporating leaflet anisotropy with pronounced stiffness in the circumferential direction through a transverse isotropic model. The parameters for the hyperelastic models were obtained from fits to results of orthogonal uniaxial tensile tests on porcine aortic valve leaflets. The computational results indicated the significant impact of transverse isotropy and hyperelastic effects on leaflet mechanics; in particular, increased coaptation with peak values of stress and strain in the elastic limit. The alignment of maximum principal stresses in all models follows approximately the coarse collagen fibre distribution found in aortic valve leaflets. The non-linear elastic leaflets also demonstrated more evenly distributed stress and strain which appears relevant to long-term scaffold stability and mechanotransduction. © 2010 Taylor & Francis.
Authors & Co-Authors
Koch, T. M.
South Africa, Cape Town
University of Cape Town
South Africa, Cape Town
Faculty of Health Sciences
Reddy, B. D.
South Africa, Cape Town
University of Cape Town
Zilla, Peter P.
South Africa, Cape Town
Faculty of Health Sciences
Franz, Thomas
South Africa, Cape Town
Faculty of Health Sciences
Statistics
Citations: 68
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1080/10255840903120160
ISSN:
10255842
e-ISSN:
14768259