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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Transmission dynamics of the M184V drug resistance mutation in primary HIV infection
Journal of Antimicrobial Chemotherapy, Volume 66, No. 10, Article dkr291, Year 2011
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Description
Objectives: M184V in HIV-1 reverse transcriptase is among the most common mutations in patients failing antiretroviral therapy but is found only rarely in cases of transmitted drug resistance. Methods: To investigate this apparent paradox, we developed an allele-specific real-time PCR (AS-PCR) assay to determine the transmission of M184V in newly infected individuals. Results: M184V transmission may occur to a greater extent than previously thought. Persistence of M184V may commonly involve linkage to other drug resistance mutations. The presence of M184V as a single substitution in newly infected individuals was shown to wane over time, as a likely consequence of reversion and overgrowth by more fit wild-type viruses. Conclusions: The M184V mutation can be documented in newly infected individuals, and the alternative hypothesis that this substitution might impact on the ability of HIV to be transmitted is unfounded. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Authors & Co-Authors
Wainberg, Mark A.
Canada, Montreal
Institut Lady Davis de Recherches Médicales
Canada, Montreal
Université Mcgill
Moïsi, Daniella D.
Canada, Montreal
Institut Lady Davis de Recherches Médicales
Oliveira, Maureen
Canada, Montreal
Institut Lady Davis de Recherches Médicales
Toni, Thomas D’Aquin
Canada, Montreal
Institut Lady Davis de Recherches Médicales
Canada, Montreal
Université Mcgill
Cote D'ivoire, Abidjan
Programme Pacci-cirba
Brenner, Bluma G.
Canada, Montreal
Institut Lady Davis de Recherches Médicales
Statistics
Citations: 38
Authors: 5
Affiliations: 3
Identifiers
Doi:
10.1093/jac/dkr291
ISSN:
03057453
e-ISSN:
14602091
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases