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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Atherogenic effects in a non-human primate of Fusarium moniliforme cultures added to a carbohydrate diet
Atherosclerosis, Volume 94, No. 1, Year 1992
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Description
Adding less than 0.5% w/w of culture material of strain MRC 826 of the fungus Fusarium moniliforme to a carbohydrate diet low in fat resulted in an atherogenic plasma lipid profile in a non-human primate. Simultaneously increased plasma fibrinogen and activity of blood coagulation factor VII could enhance atherogenesis. This unique potential for promotion of atherosclerosis was probably secondary to chronic hepatotoxicity as indicated by liver fibrosis and elevated cholesterol, albumin and the enzymes AST, ALT, LD, GGT and ALP in serum. The cholesterol and enzymes responded in proportion to the calculated doses of fumonisin mycotoxins in the F. moniliforme MRC 826 cultures. Fumonisins are water soluble and heat stable. Thrombotic, hepatotoxic, carcinogenic and cerebral effects of MRC 826 culture material and fumonisins are well known in non-primates. The estimated fumonisin concentrations tested fall within a range due to natural contamination of human foods. The results suggest that all maize grain products should be analysed for fumonisins. © 1992.
Authors & Co-Authors
Fincham, John E.
South Africa, Tygerberg
South African Medical Research Council
Marasas, W. F. O.
South Africa, Tygerberg
South African Medical Research Council
Taljaard, Joshua Joachim Fransua
South Africa, Tygerberg
Tygerberg Hospital
Kriek, Nicolaas P.J.
South Africa, Pretoria
University of Pretoria
Badenhorst, Charl J.
South Africa, Tygerberg
South African Medical Research Council
Gelderblom, Wentzel C.A.
South Africa, Tygerberg
South African Medical Research Council
Seier, Jürgen V.
South Africa, Tygerberg
South African Medical Research Council
Smuts, Cornelius Marius
South Africa, Tygerberg
South African Medical Research Council
Faber, Mieke M.
South Africa, Tygerberg
South African Medical Research Council
Weight, Michael J.
South Africa, Tygerberg
South African Medical Research Council
Slazus, W.
South Africa, Tygerberg
Tygerberg Hospital
Woodroof, Colin William
South Africa, Tygerberg
South African Medical Research Council
Van Wyk, M. J.
South Africa, Tygerberg
South African Medical Research Council
Kruger, Marita
South Africa, Tygerberg
South African Medical Research Council
Thiel, Pieter G.
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 89
Authors: 15
Affiliations: 3
Identifiers
Doi:
10.1016/0021-9150(92)90183-H
Research Areas
Environmental