Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Increased risk of virologic failure to the first antiretroviral regimen in HIV-infected migrants compared to natives: Data from the ICONA cohort
Clinical Microbiology and Infection, Volume 22, No. 3, Year 2016
Notification
URL copied to clipboard!
Description
Migrant and Italian HIV-infected patients (n = 5773) enrolled in the ICONA cohort in 2004-2014 were compared for disparities in access to an initial antiretroviral regimen and/or risk of virologic failure (VF), and determinants of failure were evaluated. Variables associated with initiating antiretroviral therapy (ART) were analysed. Primary endpoint was time to failure after at least 6 months of ART and was defined as: VF, first of two consecutive virus loads (VL) >200 copies/mL; treatment discontinuation (TD) for any reason; and treatment failure as confirmed VL >200 copies/mL or TD. A Poisson multivariable analysis was performed to control for confounders. Migrants presented significantly lower CD4 counts and more frequent AIDS events at baseline. When adjusting for baseline confounders, migrants presented a lower likelihood to begin ART (odds ratio 0.80, 95% confidence interval (CI) 0.67-0.95, p 0.012). After initiating ART, the incidence VF rate was 6.4 per 100 person-years (95% CI 4.8-8.5) in migrants and 2.7 in natives (95% CI 2.2-3.3). Multivariable analysis confirmed that migrants had a higher risk of VF (incidence rate ratio 1.90, 95% CI 1.25-2.91, p 0.003) and treatment failure (incidence rate ratio 1.16, 95% CI 1.01-1.33, p 0.031), with no differences for TD. Among migrants, variables associated with VF were age, unemployment and use of a boosted protease inhibitor-based regimen versus nonnucleoside reverse transcriptase inhibitors. Despite the use of more potent and safer drugs in the last 10 years, and even in a universal health care setting, migrants living with HIV still present barriers to initiating ART and an increased risk of VF compared to natives. © 2015 European Society of Clinical Microbiology and Infectious Diseases.
Authors & Co-Authors
Saracino, Annalisa L.
Italy, Bari
Università Degli Studi Di Bari Aldo Moro
Lorenzini, Patrizia
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Lo Caputo, Sergio
Italy, Florence
Azienda Sanitaria Di Firenze
Girardi, Enrico
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Castelli, Francesco
Italy, Brescia
Spedali Civili Di Brescia
Bonfanti, Paolo
Italy, Lecco
Azienda Ospedaliera Ospedale Di Lecco
Rusconi, Stefano
Italy, Milan
Università Degli Studi Di Milano
Caramello, Pietro
Italy, Turin
Ospedale Amedeo Di Savoia
Mussini, Cristina
Italy, Modena
Università Degli Studi Di Modena e Reggio Emilia
Monno, Laura
Italy, Milan
Università Degli Studi Di Milano
D'Arminio Monforte, Antonella D.
Italy, Milan
Università Degli Studi Di Milano
Andreoni, Massimo G.
Unknown Affiliation
Angarano, Gioacchino
Unknown Affiliation
Antinori, Andrea
Unknown Affiliation
Cauda, Roberto
Unknown Affiliation
Di Perri, Giovanni
Unknown Affiliation
Galli, Massimo
Unknown Affiliation
Iardino, Rosaria
Unknown Affiliation
Ippolito, Giuseppe
Unknown Affiliation
Lazzarin, Adriano
Unknown Affiliation
Perno, Carlo Federico
Unknown Affiliation
Viale, Pierluigi
Unknown Affiliation
Castagna, Antonella
Unknown Affiliation
Cozzi-Lepri, Alessandro
Unknown Affiliation
Puoti, Massimo
Unknown Affiliation
Ammassari, Adriana
Unknown Affiliation
Balotta, Claudia
Unknown Affiliation
Bonora, Stefano
Unknown Affiliation
Borderi, M.
Unknown Affiliation
Capobianchi, Maria Rosaria
Unknown Affiliation
Ceccherini-Silberstein, Francesca
Unknown Affiliation
Cingolani, A.
Unknown Affiliation
Cinque, P.
Unknown Affiliation
De Luca, Andrea
Unknown Affiliation
Di Biagio, Antonio
Unknown Affiliation
Gianotti, Nicola
Unknown Affiliation
Gori, Andrea
Unknown Affiliation
Guaraldi, Giovanni
Unknown Affiliation
Lapadula, Giuseppe
Unknown Affiliation
Lichtner, Miriam
Unknown Affiliation
Maggiolo, Franco
Unknown Affiliation
Quiròs-Roldan, Eugenia
Unknown Affiliation
Cicconi, Paola
Unknown Affiliation
Fanti, Iuri
Unknown Affiliation
Galli, Luisa
Unknown Affiliation
Tavelli, Alessandro
Unknown Affiliation
Giacometti, Andrea R.
Unknown Affiliation
Verucchi, Gabriella
Unknown Affiliation
Quirino, Tiziana
Unknown Affiliation
Segala, D.
Unknown Affiliation
Mazzotta, Francesco
Unknown Affiliation
Viscoli, Claudio
Unknown Affiliation
Mastroianni, Claudio Maria
Unknown Affiliation
Castelli, Antonio P.
Unknown Affiliation
Rizzardini, Giuliano
Unknown Affiliation
Ridolfo, Anna Lisa
Unknown Affiliation
Carenzi, Laura
Unknown Affiliation
Tincati, Camilla
Unknown Affiliation
Chirianni, Antonio
Unknown Affiliation
Parruti, Giustino
Unknown Affiliation
Ursini, T.
Unknown Affiliation
Vullo, Vincenzo
Unknown Affiliation
Nicastri, Emanuele
Unknown Affiliation
Acinapura, Rosa
Unknown Affiliation
Libertone, Raffaella
Unknown Affiliation
Zaccarelli, Mauro
Unknown Affiliation
Rossetti, Barbara
Unknown Affiliation
Orofino, Giancarlo
Unknown Affiliation
Bassetti, Matteo
Unknown Affiliation
Pellizzer, Giampietro P.
Unknown Affiliation
Manfrin, Vinicio
Unknown Affiliation
Statistics
Citations: 29
Authors: 71
Affiliations: 9
Identifiers
Doi:
10.1016/j.cmi.2015.10.026
ISSN:
1198743X
Research Areas
Health System And Policy
Infectious Diseases
Study Design
Cohort Study
Case-Control Study