Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Maternal vitamin D supplementation to improve the vitamin D status of breast-fed infants: A randomized controlled trial
Mayo Clinic Proceedings, Volume 88, No. 12, Year 2013
Notification
URL copied to clipboard!
Description
Objective: To determine whether a single monthly supplement is as effective as a daily maternal supplement in increasing breast milk vitamin D to achieve vitamin D sufficiency in their infants. Patients and Methods: Forty mothers with exclusively breast-fed infants were randomized to receive oral cholecalciferol (vitamin D3) 5000 IU/d for 28 days or 150,000 IU once. Maternal serum, breast milk, and urine were collected on days 0, 1, 3, 7, 14, and 28; infant serum was obtained on days 0 and 28. Enrollment occurred between January 7, 2011, and July 29, 2011. Results: In mothers given daily cholecalciferol, concentrations of serum and breast milk cholecalciferol attained steady levels of 18 and 8 ng/mL, respectively, from day 3 through 28. In mothers given the single dose, serum and breast milk cholecalciferol peaked at 160 and 40 ng/mL, respectively, at day 1 before rapidly declining. Maternal milk and serum cholecalciferol concentrations were related (r=0.87). Infant mean serum 25-hydroxyvitamin D concentration increased from 17±13 to 39±6 ng/mL in the single-dose group and from 16±12 to 39±12 ng/mL in the daily-dose group (P=.88). All infants achieved serum 25-hydroxyvitamin D concentrations of more than 20 ng/mL. Conclusion: Either single-dose or daily-dose cholecalciferol supplementation of mothers provided breast milk concentrations that result in vitamin D sufficiency in breast-fed infants. © 2013 Mayo Foundation for Medical Education and Research.
Authors & Co-Authors
Oberhelman, Sara S.
United States, Rochester
Mayo Clinic
Meekins, Michael E.
United States, Rochester
Mayo Clinic
Fischer, Philip R.
United States, Rochester
Mayo Clinic
Lee, Bernard R.
United States, Rochester
Mayo Clinic
United States, Minneapolis
College of Pharmacy
Singh, Ravinder Jit
United States, Rochester
Mayo Clinic
Cha, Stephen S.
United States, Rochester
Mayo Clinic
Gardner, Brian M.
United States, Rochester
Mayo Clinic
United States, Lexington
University of Kentucky
Pettifor, John M.
South Africa, Johannesburg
University of the Witwatersrand
Croghan, Ivana T.
United States, Rochester
Mayo Clinic
Thacher, Tom D.
United States, Rochester
Mayo Clinic
Statistics
Citations: 89
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/j.mayocp.2013.09.012
ISSN:
00256196
Research Areas
Health System And Policy
Maternal And Child Health
Study Approach
Quantitative