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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The effect of different combination therapies on oxidative stress markers in HIV infected patients in Cameroon
AIDS Research and Therapy, Volume 3, No. 1, Article 19, Year 2006
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Description
The study assessed the effect of some highly active antiretroviral therapies (HAART), used in the management of HIV/AIDS in Cameroon, on oxidative stress markers such as malondialdehyde (as TBARs), albumin, protein carbonyl content and protein sulfhydryls groups. 85 HIV positive patients (34.8 ± 9.3 years) were on three different highly active antiretroviral therapies (HAART patients). 65 HIV positive patients (32.2 ± 10.9 years) on no treatment (Pre-HAART patients), and 90 non-HIV infected patients (32.6 ± 9.3 years), were the control groups. Plasma TBARs as well as carbonyl levels were significantly higher in HIV patients on HAART compared to pre-HAART patients or non-HIV infected controls. On the other hand, the protein sulfhydryl group content was not different for patients on HAART compared to pre-HAART patients, but both were significantly lower than non-HIV infected controls (P < 0.0001, 0.001). The combination treatment Therapy I [stavudin (80 mg) + Lamivudin (600 mg) + Nevirapin + (400 mg) zidovudin (600 mg)] brought about a significant (p < 0.05) reduction in the plasma concentration of protein sulfhydrl groups as well as TBARs compared to Therapy II [stavudin (80 mg) + Lamivudin (300 mg) + nevirapin (400 mg)] or with combination Therapy III of [zidovudine (600 mg) + lamivudin(300 mg) with efavirenz (600 mg)] (P < 0.05). The content of the antioxidant, Vitamin C was lower in the plasma of patients on Therapy I compared to those on Therapy II (P < 0.01) and Therapy III (P < 0.001). HIV infection therefore increases the oxidative stress process, while antiretroviral combination therapy increased protein oxidation as well as the level of oxidative stress already present in HIV infection. © 2006 Ngondi et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Ngondi, Judith Laure
Cameroon, Yaounde
Université de Yaoundé I
Oben, Julius Enyong
Cameroon, Yaounde
Université de Yaoundé I
Forkah, David Musoro
Cameroon, Yaounde
Université de Yaoundé I
Etame, Lucein Honore
Cameroon, Yaounde
Université de Yaoundé I
Mbanya, Dora Ngum Shu
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 110
Authors: 5
Affiliations: 1
Identifiers
Doi:
10.1186/1742-6405-3-19
ISSN:
17426405
Research Areas
Infectious Diseases
Study Locations
Cameroon