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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Signalling through MyD88 drives surface expression of the mycobacterial receptors MCL (Clecsf8, Clec4d) and Mincle (Clec4e) following microbial stimulation
Microbes and Infection, Volume 18, No. 7-8, Year 2016
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Description
The heterodimeric mycobacterial receptors, macrophage C-type lectin (MCL) and macrophage inducible C-type lectin (Mincle), are upregulated at the cell surface following microbial challenge, but the mechanisms underlying this response are unclear. Here we report that microbial stimulation triggers Mincle expression through the myeloid differentiation primary response gene 88 (MyD88) pathway; a process that does not require MCL. Conversely, we show that MCL is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface. Thus this “two-step” model for induction of these key receptors provides new insights into the underlying mechanisms of anti-mycobacterial immunity. © 2016 The Authors
Authors & Co-Authors
Kerscher, Bernhard
United Kingdom, Aberdeen
University of Aberdeen
Dambuza, Ivy M.
United Kingdom, Aberdeen
University of Aberdeen
Reid, Delyth M.
United Kingdom, Aberdeen
University of Aberdeen
Yamasaki, S.
Japan, Fukuoka
Kyushu University
Willment, Janet Anne
United Kingdom, Aberdeen
University of Aberdeen
Brown, Gordon D.A.
United Kingdom, Aberdeen
University of Aberdeen
Statistics
Citations: 23
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.micinf.2016.03.007
ISSN:
12864579
Research Areas
Genetics And Genomics